Detailed information of TA system TA169412

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-rdlD/Ldr(toxin)
• Location: 4619979..4620201
• Replicon: chromosome
• Accession: NZ_CP059917
• Organism: Escherichia coli strain 64.1

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: H5C78_RS22225
• Protein ID: WP_001295224.1
• Coordinates: 4619979..4620086 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	4620143..4620201 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H5C78_RS22200	4615263..4616834	+	1572	WP_182917240.1	cellulose biosynthesis protein BcsE	-
H5C78_RS22205	4616831..4617022	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
H5C78_RS22210	4617019..4618698	+	1680	WP_001562264.1	cellulose biosynthesis protein BcsG	-
H5C78_RS22215	4618813..4619271	-	459	WP_000526135.1	IS200/IS605 family transposase	-
H5C78_RS22220	4619496..4619603	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
H5C78_RS22225	4619979..4620086	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4620143..4620201	+	59	-	-	Antitoxin
H5C78_RS22230	4620462..4620569	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	-
H5C78_RS22235	4620945..4621052	-	108	WP_000170738.1	type I toxin-antitoxin system toxin Ldr family protein	-
H5C78_RS22240	4621528..4622799	+	1272	WP_001318103.1	amino acid permease	-
H5C78_RS22245	4622829..4623833	-	1005	WP_000107036.1	dipeptide ABC transporter ATP-binding subunit DppF	-
H5C78_RS22250	4623830..4624813	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4618813..4619271	458

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T169412 WP_001295224.1 NZ_CP059917:c4620086-4619979 [Escherichia coli]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T169412 NZ_CP076470:c2973651-2973322 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT169412 NZ_CP059917:4620143-4620201 [Escherichia coli]
TCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin