Detailed information of TA system TA169321

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3838374..3838882
• Replicon: chromosome
• Accession: NZ_CP059900
• Organism: Tomitella sp. HY172

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H4F70_RS17805
• Protein ID: WP_182358179.1
• Coordinates: 3838374..3838634 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H4F70_RS17810
• Protein ID: WP_182358180.1
• Coordinates: 3838631..3838882 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H4F70_RS17790	3834279..3835532	+	1254	WP_182358177.1	phosphatase PAP2 family protein	-
H4F70_RS17795	3835661..3836717	+	1057	Protein_3493	phosphotransferase family protein	-
H4F70_RS17800	3836755..3838332	-	1578	WP_182358178.1	hypothetical protein	-
H4F70_RS17805	3838374..3838634	-	261	WP_182358179.1	Txe/YoeB family addiction module toxin	Toxin
H4F70_RS17810	3838631..3838882	-	252	WP_182358180.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H4F70_RS17815	3839090..3840448	-	1359	WP_182358181.1	MFS transporter	-
H4F70_RS17820	3840518..3841546	-	1029	WP_182358182.1	glutathione S-transferase C-terminal domain-containing protein	-
H4F70_RS17825	3841681..3842277	+	597	WP_182358183.1	class I SAM-dependent methyltransferase	-
H4F70_RS17830	3842539..3843753	+	1215	WP_182358184.1	alkane 1-monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-73)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10491.91 Da
• Isoelectric Point: 9.4584

>T169321 WP_182358179.1 NZ_CP059900:c3838634-3838374 [Tomitella sp. HY172]
MRLVWDEAAWDDYLWWQAQDRKTLKRINALIRDIQRNGNEGIGKPEQLRHGFQGYWSRRITLEHRLVYKIIGDEIRFAAC
RYHYGE

Nucleotide

• Length: 261 bp

>T169321 NZ_CP076404:c1603565-1603278 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9401.53 Da
• Isoelectric Point: 4.4674

>AT169321 WP_182358180.1 NZ_CP059900:c3838882-3838631 [Tomitella sp. HY172]
VRTISYSESRARYAETLDSVIDDREEVIVTRAGRDPVVMVALDEYESLKETAYLLKSPENARRLLASIKRLESGEGVERD
LAE

Nucleotide

• Length: 252 bp

>AT169321 NZ_CP076404:c1603804-1603565 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA