Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3007393..3007999 Replicon chromosome
Accession NZ_CP059900
Organism Tomitella sp. HY172

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag H4F70_RS13880 Protein ID WP_182346916.1
Coordinates 3007393..3007674 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag H4F70_RS13885 Protein ID WP_182357596.1
Coordinates 3007694..3007999 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F70_RS13860 3002875..3003888 + 1014 WP_182357594.1 lipoyl synthase -
H4F70_RS13865 3003955..3004698 + 744 WP_182357595.1 DUF4191 domain-containing protein -
H4F70_RS13870 3004727..3005194 - 468 WP_182347012.1 RDD family protein -
H4F70_RS13875 3005441..3006874 + 1434 WP_182346917.1 type I glutamate--ammonia ligase -
H4F70_RS13880 3007393..3007674 + 282 WP_182346916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4F70_RS13885 3007694..3007999 + 306 WP_182357596.1 HigA family addiction module antidote protein Antitoxin
H4F70_RS13890 3008301..3010796 + 2496 WP_182357597.1 M20/M25/M40 family metallo-hydrolase -
H4F70_RS13895 3010925..3011620 + 696 WP_182357598.1 ABC transporter permease -
H4F70_RS13900 3011613..3012908 + 1296 WP_182357599.1 ATP-binding cassette domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10698.00 Da        Isoelectric Point: 8.0650

>T169320 WP_182346916.1 NZ_CP059900:3007393-3007674 [Tomitella sp. HY172]
VIRSFKNTDTEKVWNREHVRALGPELQRAAQKTLRLLNAASELNSLRVPPGNRLEKLVGDRAGQHSIRINDQYRICFVWT
DNGADDVEITDYH

Download         Length: 282 bp

>T169320 NZ_CP076404:1467919-1468095 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11286.89 Da        Isoelectric Point: 4.6533

>AT169320 WP_182357596.1 NZ_CP059900:3007694-3007999 [Tomitella sp. HY172]
MAETTKAHDPITPGEILLTEFLEPLGITQYRLAQATGLPQTRISEIVRGKRAITIDTALRLSKTLGVDDRFWINIQTDYD
LEVERDLHADELAKVTPLVAS

Download         Length: 306 bp

>AT169320 NZ_CP076404:1468141-1468557 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References