Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2978645..2979153 Replicon chromosome
Accession NZ_CP059898
Organism Streptomyces sp. M54

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag H3V39_RS12715 Protein ID WP_206977463.1
Coordinates 2978893..2979153 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1G6UDZ1
Locus tag H3V39_RS12710 Protein ID WP_030115528.1
Coordinates 2978645..2978896 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3V39_RS12695 2975576..2976298 + 723 WP_032751179.1 hypothetical protein -
H3V39_RS12700 2976372..2977499 + 1128 WP_206977461.1 hypothetical protein -
H3V39_RS12705 2977496..2978560 + 1065 WP_206977462.1 hypothetical protein -
H3V39_RS12710 2978645..2978896 + 252 WP_030115528.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H3V39_RS12715 2978893..2979153 + 261 WP_206977463.1 Txe/YoeB family addiction module toxin Toxin
H3V39_RS12720 2979157..2980491 - 1335 WP_206977464.1 acyltransferase family protein -
H3V39_RS12725 2980835..2981569 + 735 WP_206977465.1 hypothetical protein -
H3V39_RS12730 2981571..2982476 - 906 WP_206977466.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
H3V39_RS12735 2982473..2983345 - 873 WP_043249565.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10317.63 Da        Isoelectric Point: 9.7527

>T169313 WP_206977463.1 NZ_CP059898:2978893-2979153 [Streptomyces sp. M54]
VKFVWDQSSWDDYVWWQNQDRKILKRINALLQDIARNGNEGMGKPDPLKHGFHGYWSRRITGEHRLIYKVGDDEVRVAAC
RYHYGR

Download         Length: 261 bp

>T169313 NZ_CP076386:c4760987-4760907 [Dickeya dadantii]
AATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGGGCACAGGAATCGTGTTCGGTCTTTTTT
T

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9343.42 Da        Isoelectric Point: 4.5447

>AT169313 WP_030115528.1 NZ_CP059898:2978645-2978896 [Streptomyces sp. M54]
MRTMTYTESRAKYAETLSSVVDDREEVVVTRAGHEPVVIVALDEYESLKETAYQLRSPENARRLLASIDRLENGGGTVRE
LAE

Download         Length: 252 bp

>AT169313 NZ_CP076386:4760900-4760987 [Dickeya dadantii]
AACACATAAAAAAAGACCGAACACGATTCCTGTGCCCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1G6UDZ1

References