Detailed information of TA system TA169276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 2935199..2935716
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H3309_RS14710
• Protein ID: WP_182295552.1
• Coordinates: 2935199..2935465 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H3309_RS14715
• Protein ID: WP_182295553.1
• Coordinates: 2935462..2935716 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS14665	2930338..2930580	+	243	WP_182295540.1	accessory factor UbiK family protein	-
H3309_RS14670	2930649..2931218	+	570	WP_182295542.1	YbjN domain-containing protein	-
H3309_RS14675	2931567..2931878	+	312	WP_182295544.1	hypothetical protein	-
H3309_RS14680	2932011..2932787	+	777	WP_182295546.1	enoyl-CoA hydratase/isomerase family protein	-
H3309_RS14685	2932793..2933515	+	723	WP_182298816.1	N-formylglutamate amidohydrolase	-
H3309_RS14690	2933512..2934189	+	678	WP_182295548.1	monofunctional biosynthetic peptidoglycan transglycosylase	-
H3309_RS14695	2934186..2934527	-	342	WP_182295550.1	hypothetical protein	-
H3309_RS14700	2934529..2934774	-	246	WP_182295551.1	hypothetical protein	-
H3309_RS14710	2935199..2935465	-	267	WP_182295552.1	Txe/YoeB family addiction module toxin	Toxin
H3309_RS14715	2935462..2935716	-	255	WP_182295553.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H3309_RS14720	2935797..2937077	+	1281	WP_182295554.1	serine--tRNA ligase	-
H3309_RS14725	2937077..2937832	+	756	WP_182298817.1	5'/3'-nucleotidase SurE	-
H3309_RS14730	2938078..2939376	+	1299	WP_182295555.1	homoserine dehydrogenase	-
H3309_RS14735	2939500..2940441	+	942	WP_182298818.1	class II fructose-bisphosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10482.03 Da
• Isoelectric Point: 8.8836

>T169276 WP_182295552.1 NZ_CP059851:c2935465-2935199 [Sandaracinobacter sp. M6]
VIIVFFPTAWTAYCHWQATDRQTLERLNALIEECCRHPFTGTGKPEPLKNELKGFWSRRITREDRLVYRVAGQGKEQRLE
IAQCRFHY

Nucleotide

• Length: 267 bp

>T169276 NZ_CP076344:c4021007-4020693 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9205.43 Da
• Isoelectric Point: 4.7164

>AT169276 WP_182295553.1 NZ_CP059851:c2935716-2935462 [Sandaracinobacter sp. M6]
MRAMHYSDTRANLKTVMDRVVDDHEPVIVTRRNGEPVVIVSLSDWNSMDETAYLLSTPANAAALREAVAGLNAGLGVERE
LINP

Nucleotide

• Length: 255 bp

>AT169276 NZ_CP076344:c4020696-4020280 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA