Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2273552..2274189 Replicon chromosome
Accession NZ_CP059843
Organism Cobetia sp. 4B

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H2O77_RS09575 Protein ID WP_215822797.1
Coordinates 2273896..2274189 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H2O77_RS09570 Protein ID WP_215822795.1
Coordinates 2273552..2273881 (-) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2O77_RS09550 (H2O77_09535) 2269649..2270113 + 465 WP_215822789.1 carboxypeptidase regulatory-like domain-containing protein -
H2O77_RS09555 (H2O77_09540) 2270178..2270912 + 735 WP_215822791.1 AraC family transcriptional regulator -
H2O77_RS09560 (H2O77_09545) 2271107..2272108 + 1002 WP_215822793.1 DMT family transporter -
H2O77_RS09565 (H2O77_09550) 2272415..2273407 + 993 WP_240548565.1 EamA family transporter -
H2O77_RS09570 (H2O77_09555) 2273552..2273881 - 330 WP_215822795.1 HigA family addiction module antitoxin Antitoxin
H2O77_RS09575 (H2O77_09560) 2273896..2274189 - 294 WP_215822797.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2O77_RS09580 (H2O77_09565) 2274375..2275637 - 1263 WP_215824553.1 cytosine permease -
H2O77_RS09585 (H2O77_09570) 2276193..2278631 - 2439 WP_215822799.1 FdhF/YdeP family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11261.76 Da        Isoelectric Point: 8.0778

>T169251 WP_215822797.1 NZ_CP059843:c2274189-2273896 [Cobetia sp. 4B]
MAVEFRDVWLESFYEHDVGHRKIPAALSSSLYRKLQILDAASQESDLRIPPGNRFEHLQGNLAGYCSIRVNKQYRLIFRW
EAGIAHQTYLDPHAYKG

Download         Length: 294 bp

>T169251 NZ_CP076318:2628219-2628683 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 12268.11 Da        Isoelectric Point: 7.4712

>AT169251 WP_215822795.1 NZ_CP059843:c2273881-2273552 [Cobetia sp. 4B]
MRNTQRRPLTVGEMLTAEFLEPMDIDIRTLAEAMGVHRNTLSRIVHDKGTLTAPMAIKLAAALGNTPEFWLNIQHAVELW
DVRHRAYAQDAKGVRRITPQVDATELASH

Download         Length: 330 bp

>AT169251 NZ_CP076318:2627884-2628219 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References