169181

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32634..33153 Replicon plasmid pA15023_P2
Accession NZ_CP059825
Organism Enterococcus faecium strain A15023

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI843_RS14870 Protein ID WP_000588503.1
Coordinates 32896..33153 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI843_RS14865 Protein ID WP_000388479.1
Coordinates 32634..32903 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI843_RS14830 28205..28621 - 417 WP_001232859.1 hypothetical protein -
HI843_RS14835 28624..28908 - 285 WP_000353844.1 hypothetical protein -
HI843_RS14840 29253..29498 + 246 WP_002311817.1 hypothetical protein -
HI843_RS14845 29800..29895 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
HI843_RS14850 30621..31301 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
HI843_RS14855 31377..31943 + 567 Protein_37 hypothetical protein -
HI843_RS14860 32324..32503 + 180 WP_001120991.1 hypothetical protein -
HI843_RS14865 32634..32903 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI843_RS14870 32896..33153 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI843_RS14875 33791..34378 + 588 Protein_41 hypothetical protein -
HI843_RS14880 34533..35852 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
HI843_RS14885 36056..36298 + 243 Protein_43 hypothetical protein -
HI843_RS14890 36463..37077 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..41614 41614
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..35852 34195


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169181 WP_000588503.1 NZ_CP059825:32896-33153 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169181 NZ_CP076301:108078-108332 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169181 WP_000388479.1 NZ_CP059825:32634-32903 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169181 NZ_CP076301:107830-108081 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References