Detailed information of TA system TA169181

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Txe-Axe/Txe-RelB
• Location: 32634..33153
• Replicon: plasmid pA15023_P2
• Accession: NZ_CP059825
• Organism: Enterococcus faecium strain A15023

Toxin (Protein)

• Gene name: Txe
• Uniprot ID: Q848U6
• Locus tag: HI843_RS14870
• Protein ID: WP_000588503.1
• Coordinates: 32896..33153 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: Axe
• Uniprot ID: Q83WJ8
• Locus tag: HI843_RS14865
• Protein ID: WP_000388479.1
• Coordinates: 32634..32903 (+)
• Length: 90 a.a.

Genomic Context

Location: 29253..29498 (246 bp)
Type: Others
Protein ID: WP_002311817.1

Location: 31377..31943 (567 bp)
Type: Others
Protein ID: Protein_37

Location: 32324..32503 (180 bp)
Type: Others
Protein ID: WP_001120991.1

Location: 32634..32903 (270 bp)
Type: Antitoxin
Protein ID: WP_000388479.1

Location: 32896..33153 (258 bp)
Type: Toxin
Protein ID: WP_000588503.1

Location: 33791..34378 (588 bp)
Type: Others
Protein ID: Protein_41

Location: 34533..35852 (1320 bp)
Type: Others
Protein ID: WP_000202380.1

Location: 36056..36298 (243 bp)
Type: Others
Protein ID: Protein_43

Location: 28205..28621 (417 bp)
Type: Others
Protein ID: WP_001232859.1

Location: 28624..28908 (285 bp)
Type: Others
Protein ID: WP_000353844.1

Location: 29800..29895 (96 bp)
Type: Others
Protein ID: WP_106913803.1

Location: 30621..31301 (681 bp)
Type: Others
Protein ID: WP_001015311.1

Location: 36463..37077 (615 bp)
Type: Others
Protein ID: WP_001261742.1

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Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI843_RS14830	28205..28621	-	417	WP_001232859.1	hypothetical protein	-
HI843_RS14835	28624..28908	-	285	WP_000353844.1	hypothetical protein	-
HI843_RS14840	29253..29498	+	246	WP_002311817.1	hypothetical protein	-
HI843_RS14845	29800..29895	-	96	WP_106913803.1	type I toxin-antitoxin system Fst family toxin	-
HI843_RS14850	30621..31301	-	681	WP_001015311.1	IS6-like element IS1216 family transposase	-
HI843_RS14855	31377..31943	+	567	Protein_37	hypothetical protein	-
HI843_RS14860	32324..32503	+	180	WP_001120991.1	hypothetical protein	-
HI843_RS14865	32634..32903	+	270	WP_000388479.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
HI843_RS14870	32896..33153	+	258	WP_000588503.1	Txe/YoeB family addiction module toxin	Toxin
HI843_RS14875	33791..34378	+	588	Protein_41	hypothetical protein	-
HI843_RS14880	34533..35852	+	1320	WP_000202380.1	IS1380-like element IS1678 family transposase	-
HI843_RS14885	36056..36298	+	243	Protein_43	hypothetical protein	-
HI843_RS14890	36463..37077	-	615	WP_001261742.1	recombinase family protein	-

Associated MGEs

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MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	Similar MGE(s) Similar MGE(s) is defined as other TA-related MGE(s) with Mash distance < 0.01 to this MGE. Detail Genome accession Organism MGE type Related TA Coordinates Mash distance View NC_014959 Enterococcus faecium Non-Mobilizable plasmid TA006115 1..39032 0.005	inside	Non-Mobilizable plasmid	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1..41614	41614
	-	inside	IScluster/Tn	erm(B) / ant(6)-Ia / aph(3')-III / VanHAX	-	1657..35852	34195

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10206.53 Da
• Isoelectric Point: 8.4369

>T169181 WP_000588503.1 NZ_CP059825:32896-33153 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Nucleotide

• Length: 258 bp

>T169181 NZ_CP076301:108078-108332 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10373.51 Da
• Isoelectric Point: 4.4346

>AT169181 WP_000388479.1 NZ_CP059825:32634-32903 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Nucleotide

• Length: 270 bp

>AT169181 NZ_CP076301:107830-108081 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Toxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Antitoxin

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Protein	Organism	Identities (%)	Coverage (%)	Ha-value
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Structures

Toxin

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• AlphaFold DB: A0A828ZXQ8

Antitoxin

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• AlphaFold DB: A0A828ZWU7