Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
Location | 216410..216945 | Replicon | plasmid pBP657_P1 |
Accession | NZ_CP059817 | ||
Organism | Enterococcus faecium strain BP657 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | R2PQC0 |
Locus tag | HI829_RS14760 | Protein ID | WP_002314366.1 |
Coordinates | 216410..216682 (-) | Length | 91 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | Q3Y220 |
Locus tag | HI829_RS14765 | Protein ID | WP_002297422.1 |
Coordinates | 216682..216945 (-) | Length | 88 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HI829_RS14720 | 211515..211964 | - | 450 | WP_010729386.1 | TlpA family protein disulfide reductase | - |
HI829_RS14725 | 212120..212662 | - | 543 | WP_002298088.1 | hypothetical protein | - |
HI829_RS14730 | 212937..213580 | + | 644 | Protein_230 | transposase | - |
HI829_RS14735 | 213656..214336 | + | 681 | WP_002331383.1 | IS6-like element IS1216 family transposase | - |
HI829_RS14740 | 214395..214583 | - | 189 | Protein_232 | hypothetical protein | - |
HI829_RS14745 | 214584..215441 | - | 858 | WP_002292680.1 | AAA family ATPase | - |
HI829_RS14750 | 215727..216014 | - | 288 | WP_002300557.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
HI829_RS14755 | 216004..216333 | - | 330 | WP_002292678.1 | AbrB family transcriptional regulator | - |
HI829_RS14760 | 216410..216682 | - | 273 | WP_002314366.1 | Txe/YoeB family addiction module toxin | Toxin |
HI829_RS14765 | 216682..216945 | - | 264 | WP_002297422.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HI829_RS14770 | 217179..218087 | + | 909 | Protein_238 | IS982 family transposase | - |
HI829_RS14775 | 218090..219265 | - | 1176 | WP_002336205.1 | MFS transporter | - |
HI829_RS14780 | 219268..221517 | - | 2250 | WP_002314387.1 | alpha-galactosidase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..229798 | 229798 | |
- | inside | IScluster/Tn | - | - | 204846..227546 | 22700 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 91 a.a. Molecular weight: 10780.24 Da Isoelectric Point: 9.9724
>T169175 WP_002314366.1 NZ_CP059817:c216682-216410 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ
Download Length: 273 bp
>T169175 NZ_CP076297:1398626-1398877 [Burkholderia pseudomallei]
ATGCAGCGACTGCGCGATTTTCTGCGACCGAAGAATCCTGACGCCGCAAGGCGAGCTGGCGAAGCGATTAGACAAGGCGT
ACAGGCTCTCGGTACTCACCCTCGAATGGGGCGTCTCGTAGAAGATCTACCCGAGCAGTATCGGGAGTGGCCCATCGATT
TCGGGGACAGTGGTTACGTGGCCCGGTATCGCTTCGATGGCGACGCCGTCACGATCTTGGCTGTCCGTCATCAGAAGGAA
GCGGGGTATTGA
ATGCAGCGACTGCGCGATTTTCTGCGACCGAAGAATCCTGACGCCGCAAGGCGAGCTGGCGAAGCGATTAGACAAGGCGT
ACAGGCTCTCGGTACTCACCCTCGAATGGGGCGTCTCGTAGAAGATCTACCCGAGCAGTATCGGGAGTGGCCCATCGATT
TCGGGGACAGTGGTTACGTGGCCCGGTATCGCTTCGATGGCGACGCCGTCACGATCTTGGCTGTCCGTCATCAGAAGGAA
GCGGGGTATTGA
Antitoxin
Download Length: 88 a.a. Molecular weight: 9959.22 Da Isoelectric Point: 4.5370
>AT169175 WP_002297422.1 NZ_CP059817:c216945-216682 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL
Download Length: 264 bp
>AT169175 NZ_CP076297:1398321-1398599 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCTCGTCGCCGCAC
CCCGCATTGGATCATGCGTGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGTATTGAACCAGGATACGC
TCAAGGCATGGGATGAATTTCAGGAGACTGGCCTGCACGCAACCGCCGAGGAGGTGGATAAGTGGCTTGCGAGCTGGGGA
ACTGAAAACGAACTGCCTCCGCCAGAATGCCACAAGTAA
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCTCGTCGCCGCAC
CCCGCATTGGATCATGCGTGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGTATTGAACCAGGATACGC
TCAAGGCATGGGATGAATTTCAGGAGACTGGCCTGCACGCAACCGCCGAGGAGGTGGATAAGTGGCTTGCGAGCTGGGGA
ACTGAAAACGAACTGCCTCCGCCAGAATGCCACAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F704 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A829F006 |