Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 216410..216945 Replicon plasmid pBP657_P1
Accession NZ_CP059817
Organism Enterococcus faecium strain BP657

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag HI829_RS14760 Protein ID WP_002314366.1
Coordinates 216410..216682 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag HI829_RS14765 Protein ID WP_002297422.1
Coordinates 216682..216945 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI829_RS14720 211515..211964 - 450 WP_010729386.1 TlpA family protein disulfide reductase -
HI829_RS14725 212120..212662 - 543 WP_002298088.1 hypothetical protein -
HI829_RS14730 212937..213580 + 644 Protein_230 transposase -
HI829_RS14735 213656..214336 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
HI829_RS14740 214395..214583 - 189 Protein_232 hypothetical protein -
HI829_RS14745 214584..215441 - 858 WP_002292680.1 AAA family ATPase -
HI829_RS14750 215727..216014 - 288 WP_002300557.1 type II toxin-antitoxin system RelE/ParE family toxin -
HI829_RS14755 216004..216333 - 330 WP_002292678.1 AbrB family transcriptional regulator -
HI829_RS14760 216410..216682 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
HI829_RS14765 216682..216945 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI829_RS14770 217179..218087 + 909 Protein_238 IS982 family transposase -
HI829_RS14775 218090..219265 - 1176 WP_002336205.1 MFS transporter -
HI829_RS14780 219268..221517 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..229798 229798
- inside IScluster/Tn - - 204846..227546 22700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T169175 WP_002314366.1 NZ_CP059817:c216682-216410 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T169175 NZ_CP076297:1398626-1398877 [Burkholderia pseudomallei]
ATGCAGCGACTGCGCGATTTTCTGCGACCGAAGAATCCTGACGCCGCAAGGCGAGCTGGCGAAGCGATTAGACAAGGCGT
ACAGGCTCTCGGTACTCACCCTCGAATGGGGCGTCTCGTAGAAGATCTACCCGAGCAGTATCGGGAGTGGCCCATCGATT
TCGGGGACAGTGGTTACGTGGCCCGGTATCGCTTCGATGGCGACGCCGTCACGATCTTGGCTGTCCGTCATCAGAAGGAA
GCGGGGTATTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT169175 WP_002297422.1 NZ_CP059817:c216945-216682 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT169175 NZ_CP076297:1398321-1398599 [Burkholderia pseudomallei]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAACTGAAAGGGCGGGTTCAGCACTTGGCCGAGGCTCGTCGCCGCAC
CCCGCATTGGATCATGCGTGAAGCCATTGAGCAGTACGTCGAGCGCGAGGAAAAGCGCGAGGTATTGAACCAGGATACGC
TCAAGGCATGGGATGAATTTCAGGAGACTGGCCTGCACGCAACCGCCGAGGAGGTGGATAAGTGGCTTGCGAGCTGGGGA
ACTGAAAACGAACTGCCTCCGCCAGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References