169156

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 32298..32817 Replicon plasmid pA3895_P2
Accession NZ_CP059774
Organism Enterococcus faecium strain A3895

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI845_RS14710 Protein ID WP_000588503.1
Coordinates 32560..32817 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI845_RS14705 Protein ID WP_000388479.1
Coordinates 32298..32567 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI845_RS14670 27869..28285 - 417 WP_001232859.1 hypothetical protein -
HI845_RS14675 28288..28572 - 285 WP_000353844.1 hypothetical protein -
HI845_RS14680 28917..29162 + 246 WP_002311817.1 hypothetical protein -
HI845_RS14685 29464..29559 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
HI845_RS14690 30285..30965 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
HI845_RS14695 31041..31607 + 567 Protein_37 hypothetical protein -
HI845_RS14700 31988..32167 + 180 WP_001120991.1 hypothetical protein -
HI845_RS14705 32298..32567 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI845_RS14710 32560..32817 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI845_RS14715 33455..34042 + 588 Protein_41 hypothetical protein -
HI845_RS14720 34197..35516 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
HI845_RS14725 35720..35962 + 243 Protein_43 hypothetical protein -
HI845_RS14730 36127..36741 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Non-Mobilizable plasmid erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1..41278 41278
- inside IScluster/Tn erm(B) / ant(6)-Ia / aph(3')-III / VanHAX - 1657..35516 33859


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169156 WP_000588503.1 NZ_CP059774:32560-32817 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169156 NZ_CP076285:c487808-487590 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169156 WP_000388479.1 NZ_CP059774:32298-32567 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169156 NZ_CP076285:c488208-487834 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References