Detailed information of TA system TA169145

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 1790866..1791165
• Replicon: chromosome
• Accession: NZ_CP059764
• Organism: Enterococcus faecium strain A11051

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: HI861_RS08790
• Protein ID: WP_085811512.1
• Coordinates: 1790932..1791165 (-)
• Length: 78 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	1790866..1790952 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI861_RS08770	1786705..1786899	-	195	WP_085811488.1	hypothetical protein	-
HI861_RS08775	1786899..1789463	-	2565	WP_085811487.1	trse protein	-
HI861_RS08780	1789679..1789858	-	180	WP_085811486.1	putative holin-like toxin	-
HI861_RS08785	1789899..1790594	-	696	WP_085811485.1	hypothetical protein	-
-	1790866..1790952	+	87	-	-	Antitoxin
HI861_RS08790	1790932..1791165	-	234	WP_085811512.1	putative holin-like toxin	Toxin
HI861_RS08795	1791155..1791547	-	393	WP_085811484.1	hypothetical protein	-
HI861_RS08800	1791559..1793688	-	2130	WP_085811483.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (44-77)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8599.39 Da
• Isoelectric Point: 10.4853

>T169145 WP_085811512.1 NZ_CP059764:c1791165-1790932 [Enterococcus faecium]
ITCNLGKCLWYNNRTVKFVTVAIFWKVVVLMEVSVHSLERRSLLSVAEALGLMISFGSLIATIIFGILTAVKNDKKK

Nucleotide

• Length: 234 bp

>T169145 NZ_CP076282:3454353-3454817 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Nucleotide

• Length: 87 bp

>AT169145 NZ_CP059764:1790866-1790952 [Enterococcus faecium]
CCGCTTAAGACGGTGGCGACATTAGTTATATCTAAAAAATAACCGCTGACTCGCTAAAGTAGACGGTTATTTTTTCTTGT
CATTTTT

Structures

Antitoxin