Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 233078..233613 Replicon plasmid pA10290_P1
Accession NZ_CP059756
Organism Enterococcus faecium strain A10290

Toxin (Protein)


Gene name yoeB Uniprot ID R2PQC0
Locus tag HI839_RS14790 Protein ID WP_002314366.1
Coordinates 233078..233350 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID Q3Y220
Locus tag HI839_RS14795 Protein ID WP_002297422.1
Coordinates 233350..233613 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI839_RS14750 228184..228633 - 450 WP_010729386.1 TlpA family protein disulfide reductase -
HI839_RS14755 228789..229331 - 543 WP_002298088.1 hypothetical protein -
HI839_RS14760 229606..230249 + 644 Protein_266 transposase -
HI839_RS14765 230325..231005 + 681 WP_002331383.1 IS6-like element IS1216 family transposase -
HI839_RS14770 231064..231252 - 189 Protein_268 hypothetical protein -
HI839_RS14775 231253..232110 - 858 WP_002292680.1 AAA family ATPase -
HI839_RS14780 232395..232682 - 288 WP_076713767.1 type II toxin-antitoxin system RelE/ParE family toxin -
HI839_RS14785 232672..233001 - 330 WP_002292678.1 AbrB family transcriptional regulator -
HI839_RS14790 233078..233350 - 273 WP_002314366.1 Txe/YoeB family addiction module toxin Toxin
HI839_RS14795 233350..233613 - 264 WP_002297422.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI839_RS14800 233847..234755 + 909 Protein_274 IS982 family transposase -
HI839_RS14805 234758..235933 - 1176 WP_002336205.1 MFS transporter -
HI839_RS14810 235936..238185 - 2250 WP_002314387.1 alpha-galactosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(L) / ant(6)-Ia / aph(3')-III / erm(B) - 1..246466 246466
- inside IScluster/Tn - - 221515..244214 22699


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10780.24 Da        Isoelectric Point: 9.9724

>T169141 WP_002314366.1 NZ_CP059756:c233350-233078 [Enterococcus faecium]
MNNYSVMIKNSAKADLKKIKQSNLKPQFEKVIQTLKEDPYLPTQSFEKLKPTHEGRYSRRLNRQHRVVYKVDEDEHVVEI
YSARTHYESQ

Download         Length: 273 bp

>T169141 NZ_CP076282:c2225670-2225419 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9959.22 Da        Isoelectric Point: 4.5370

>AT169141 WP_002297422.1 NZ_CP059756:c233613-233350 [Enterococcus faecium]
MAKTVLNPSSARKNFYKLLKDVNENHTEIEIISERSENNAVLIGLDDWKAIKETLLLEQIGTLGVVRKREKDDSGFTNVD
EIDWDNL

Download         Length: 264 bp

>AT169141 NZ_CP076282:c2225422-2225168 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829F704

Antitoxin

Source ID Structure
AlphaFold DB A0A829F006

References