Detailed information of TA system TA169124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/-
• Location: 5834004..5834659
• Replicon: chromosome
• Accession: NZ_CP059738
• Organism: Pseudomonas sp. 29A

Toxin (Protein)

• Gene name: higB
• Uniprot ID: A0A7H8GGM8
• Locus tag: H3303_RS25665
• Protein ID: WP_016985613.1
• Coordinates: 5834315..5834659 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H3303_RS25660
• Protein ID: WP_016985614.1
• Coordinates: 5834004..5834318 (-)
• Length: 105 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3303_RS25635	5829309..5829827	-	519	WP_175553257.1	peptide-methionine (R)-S-oxide reductase MsrB	-
H3303_RS25640	5829979..5830689	+	711	WP_175553256.1	response regulator transcription factor	-
H3303_RS25645	5830686..5832203	+	1518	WP_175553255.1	HAMP domain-containing histidine kinase	-
H3303_RS25650	5832322..5833023	+	702	WP_016985616.1	hypothetical protein	-
H3303_RS25655	5833312..5833803	-	492	WP_016985615.1	RidA family protein	-
H3303_RS25660	5834004..5834318	-	315	WP_016985614.1	helix-turn-helix domain-containing protein	Antitoxin
H3303_RS25665	5834315..5834659	-	345	WP_016985613.1	hypothetical protein	Toxin
H3303_RS25670	5834774..5835661	-	888	WP_007916939.1	heme o synthase	-
H3303_RS25675	5835673..5836008	-	336	WP_007916940.1	cytochrome o ubiquinol oxidase subunit IV	-
H3303_RS25680	5836008..5836631	-	624	WP_016985612.1	cytochrome o ubiquinol oxidase subunit III	-
H3303_RS25685	5836635..5838665	-	2031	WP_007916945.1	cytochrome o ubiquinol oxidase subunit I	-
H3303_RS25690	5838669..5839610	-	942	WP_007916947.1	ubiquinol oxidase subunit II	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (42-94)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 13327.20 Da
• Isoelectric Point: 9.6212

>T169124 WP_016985613.1 NZ_CP059738:c5834659-5834315 [Pseudomonas sp. 29A]
MRTVFFETTIFTTSVGQYLTDDEYRELQAYMQGNPLAGDVMPRTGGFRKLRWADARRGKGRRGGLRVIYYWLMNDGQFWM
FAIYDKDELDNLTAEQEKALKKAIDKELKTRGTP

Nucleotide

• Length: 345 bp

>T169124 NZ_CP076279:4190232-4190609 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTGCGTACCGACCAGCCGGAATTC
AGTGCCTGTACCCGTTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCAGGGGAAGCATCCGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 105 a.a.
• Molecular weight: 11841.80 Da
• Isoelectric Point: 10.3048

>AT169124 WP_016985614.1 NZ_CP059738:c5834318-5834004 [Pseudomonas sp. 29A]
MKKRDLFAELMQGVDEMAAQREGKITLRNTVLEDKPVPEVGAQEIVALRERLHMSQAVFAKRIRASPSTLRNWEQEKSKP
NAQAALLIRLVEKFPDMVDRLSAV

Nucleotide

• Length: 315 bp

>AT169124 NZ_CP076279:4189774-4190142 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCAGACGACAATAACGACCGCACCTGGTGGGGACTACCCAGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTCAGCCCCAGCCATCAGCATACCGTCACGCTGTATGCCAGAGGGCTGACCTGCGAAGCCGACACCCTCGGCAGCTG
TGGTTACGTTTATATGGCTGTTTATCCGACGCCAGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A7H8GGM8