Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 328877..329466 Replicon chromosome
Accession NZ_CP059588
Organism Xanthomonas oryzae pv. oryzae strain IXO651

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO651_RS01460 Protein ID WP_012443754.1
Coordinates 328877..329158 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO651_RS01465 Protein ID WP_011260746.1
Coordinates 329176..329466 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO651_RS01455 (IXO651_001465) 326530..328782 + 2253 WP_012443753.1 exodeoxyribonuclease V subunit alpha -
IXO651_RS01460 (IXO651_001470) 328877..329158 + 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO651_RS01465 (IXO651_001475) 329176..329466 + 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO651_RS01470 (IXO651_001480) 330395..331789 + 1395 WP_011260745.1 type III secretion system effector XopQ -
IXO651_RS01475 331892..332079 - 188 Protein_289 hypothetical protein -
IXO651_RS01480 (IXO651_001485) 332239..332571 - 333 WP_011260743.1 hypothetical protein -
IXO651_RS01485 (IXO651_001490) 332826..333152 + 327 WP_228329596.1 hypothetical protein -
IXO651_RS01490 (IXO651_001495) 333280..333702 + 423 WP_033013301.1 PAAR domain-containing protein -
IXO651_RS01495 (IXO651_001500) 333705..334181 + 477 WP_011260741.1 DUF4123 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 310215..352249 42034


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T169031 WP_012443754.1 NZ_CP059588:328877-329158 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T169031 NZ_CP076272:c1349414-1349307 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT169031 WP_011260746.1 NZ_CP059588:329176-329466 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT169031 NZ_CP076272:1349467-1349528 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References