Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4794730..4795319 Replicon chromosome
Accession NZ_CP059587
Organism Xanthomonas oryzae pv. oryzae strain IXO644

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO644_RS22545 Protein ID WP_012443754.1
Coordinates 4795038..4795319 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO644_RS22540 Protein ID WP_075247384.1
Coordinates 4794730..4795020 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO644_RS22510 (IXO644_022450) 4790014..4790490 - 477 WP_011260741.1 DUF4123 domain-containing protein -
IXO644_RS22515 (IXO644_022455) 4790493..4790906 - 414 WP_012443758.1 PAAR domain-containing protein -
IXO644_RS22520 (IXO644_022460) 4791065..4791370 - 306 WP_224229802.1 hypothetical protein -
IXO644_RS22525 (IXO644_022465) 4791625..4791957 + 333 WP_011260743.1 hypothetical protein -
IXO644_RS22530 4792117..4792304 + 188 Protein_4302 hypothetical protein -
IXO644_RS22535 (IXO644_022470) 4792407..4793801 - 1395 WP_011260745.1 type III secretion system effector XopQ -
IXO644_RS22540 (IXO644_022475) 4794730..4795020 - 291 WP_075247384.1 HigA family addiction module antitoxin Antitoxin
IXO644_RS22545 (IXO644_022480) 4795038..4795319 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO644_RS22550 (IXO644_022485) 4795414..4797675 - 2262 WP_075247383.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T169030 WP_012443754.1 NZ_CP059587:c4795319-4795038 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T169030 NZ_CP076272:c1348879-1348772 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10394.03 Da        Isoelectric Point: 7.2040

>AT169030 WP_075247384.1 NZ_CP059587:c4795020-4794730 [Xanthomonas oryzae pv. oryzae]
MTVLANIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT169030 NZ_CP076272:1348927-1348993 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTAAACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References