169012

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4890962..4891551 Replicon chromosome
Accession NZ_CP059583
Organism Xanthomonas oryzae pv. oryzae strain IXO365

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO365_RS23025 Protein ID WP_012443754.1
Coordinates 4891270..4891551 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO365_RS23020 Protein ID WP_011260746.1
Coordinates 4890962..4891252 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO365_RS22990 (IXO365_022890) 4886247..4886723 - 477 WP_011260741.1 DUF4123 domain-containing protein -
IXO365_RS22995 (IXO365_022895) 4886726..4887148 - 423 WP_033013301.1 PAAR domain-containing protein -
IXO365_RS23000 (IXO365_022900) 4887276..4887602 - 327 WP_228329596.1 hypothetical protein -
IXO365_RS23005 (IXO365_022905) 4887857..4888189 + 333 WP_011260743.1 hypothetical protein -
IXO365_RS23010 4888349..4888536 + 188 Protein_4398 hypothetical protein -
IXO365_RS23015 (IXO365_022910) 4888639..4890033 - 1395 WP_011260745.1 type III secretion system effector XopQ -
IXO365_RS23020 (IXO365_022915) 4890962..4891252 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO365_RS23025 (IXO365_022920) 4891270..4891551 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO365_RS23030 (IXO365_022925) 4891646..4893904 - 2259 WP_075240794.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T169012 WP_012443754.1 NZ_CP059583:c4891551-4891270 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T169012 NZ_CP076270:c2038263-2038160 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT169012 WP_011260746.1 NZ_CP059583:c4891252-4890962 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT169012 NZ_CP076270:2038122-2038393 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References