Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4800075..4800664 Replicon chromosome
Accession NZ_CP059582
Organism Xanthomonas oryzae pv. oryzae strain IXO220

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag IXO220_RS22595 Protein ID WP_012443754.1
Coordinates 4800383..4800664 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IXO220_RS22590 Protein ID WP_011260746.1
Coordinates 4800075..4800365 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO220_RS22560 (IXO220_022565) 4795360..4795836 - 477 WP_011260741.1 DUF4123 domain-containing protein -
IXO220_RS22565 (IXO220_022570) 4795839..4796261 - 423 WP_033013301.1 PAAR domain-containing protein -
IXO220_RS22570 (IXO220_022575) 4796389..4796715 - 327 WP_237384726.1 hypothetical protein -
IXO220_RS22575 (IXO220_022580) 4796970..4797302 + 333 WP_011260743.1 hypothetical protein -
IXO220_RS22580 4797462..4797649 + 188 Protein_4316 hypothetical protein -
IXO220_RS22585 (IXO220_022585) 4797752..4799146 - 1395 WP_075240796.1 type III secretion system effector XopQ -
IXO220_RS22590 (IXO220_022590) 4800075..4800365 - 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
IXO220_RS22595 (IXO220_022595) 4800383..4800664 - 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IXO220_RS22600 (IXO220_022600) 4800759..4803017 - 2259 WP_075240794.1 exodeoxyribonuclease V subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T169008 WP_012443754.1 NZ_CP059582:c4800664-4800383 [Xanthomonas oryzae pv. oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T169008 NZ_CP076270:c1338301-1338194 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT169008 WP_011260746.1 NZ_CP059582:c4800365-4800075 [Xanthomonas oryzae pv. oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT169008 NZ_CP076270:1338348-1338414 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References