Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/COG4683-HTH_37 |
| Location | 4112806..4113506 | Replicon | chromosome |
| Accession | NZ_CP059572 | ||
| Organism | Actinomadura graeca strain 32-07 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | AGRA3207_RS18015 | Protein ID | WP_231335842.1 |
| Coordinates | 4112806..4113180 (+) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | AGRA3207_RS18020 | Protein ID | WP_231335843.1 |
| Coordinates | 4113177..4113506 (+) | Length | 110 a.a. |
Genomic Context
Location: 4110306..4110740 (435 bp)
Type: Others
Protein ID: WP_231335840.1
Type: Others
Protein ID: WP_231335840.1
Location: 4110737..4112374 (1638 bp)
Type: Others
Protein ID: WP_231335841.1
Type: Others
Protein ID: WP_231335841.1
Location: 4112806..4113180 (375 bp)
Type: Toxin
Protein ID: WP_231335842.1
Type: Toxin
Protein ID: WP_231335842.1
Location: 4113177..4113506 (330 bp)
Type: Antitoxin
Protein ID: WP_231335843.1
Type: Antitoxin
Protein ID: WP_231335843.1
Location: 4114320..4115003 (684 bp)
Type: Others
Protein ID: WP_231335845.1
Type: Others
Protein ID: WP_231335845.1
Location: 4116385..4116696 (312 bp)
Type: Others
Protein ID: WP_231335847.1
Type: Others
Protein ID: WP_231335847.1
Location: 4116693..4117193 (501 bp)
Type: Others
Protein ID: WP_231335848.1
Type: Others
Protein ID: WP_231335848.1
Location: 4113879..4114262 (384 bp)
Type: Others
Protein ID: WP_231335844.1
Type: Others
Protein ID: WP_231335844.1
Location: 4115257..4115841 (585 bp)
Type: Others
Protein ID: WP_231335846.1
Type: Others
Protein ID: WP_231335846.1
Location: 4117377..4117769 (393 bp)
Type: Others
Protein ID: WP_231335849.1
Type: Others
Protein ID: WP_231335849.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| AGRA3207_RS18005 (AGRA3207_003585) | 4110306..4110740 | + | 435 | WP_231335840.1 | thioredoxin | - |
| AGRA3207_RS18010 (AGRA3207_003586) | 4110737..4112374 | + | 1638 | WP_231335841.1 | FAD-dependent oxidoreductase | - |
| AGRA3207_RS18015 (AGRA3207_003587) | 4112806..4113180 | + | 375 | WP_231335842.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| AGRA3207_RS18020 (AGRA3207_003588) | 4113177..4113506 | + | 330 | WP_231335843.1 | XRE family transcriptional regulator | Antitoxin |
| AGRA3207_RS18025 (AGRA3207_003589) | 4113879..4114262 | - | 384 | WP_231335844.1 | DUF5997 family protein | - |
| AGRA3207_RS18030 (AGRA3207_003590) | 4114320..4115003 | + | 684 | WP_231335845.1 | LysR family transcriptional regulator substrate-binding protein | - |
| AGRA3207_RS18035 (AGRA3207_003591) | 4115257..4115841 | - | 585 | WP_231335846.1 | hypothetical protein | - |
| AGRA3207_RS18040 (AGRA3207_003592) | 4116385..4116696 | + | 312 | WP_231335847.1 | GntR family transcriptional regulator | - |
| AGRA3207_RS18045 (AGRA3207_003593) | 4116693..4117193 | + | 501 | WP_231335848.1 | hypothetical protein | - |
| AGRA3207_RS18050 (AGRA3207_003594) | 4117377..4117769 | - | 393 | WP_231335849.1 | ATP-binding protein | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| No matching records found | |||||||
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 14071.01 Da Isoelectric Point: 4.7975
>T168994 WP_231335842.1 NZ_CP059572:4112806-4113180 [Actinomadura graeca]
VSWDVILLEPVESWFLKLCESDVDTAALIEQAIDRLAVVGPTLGRPLVDTLEHSELRNLKELRPGSRGRSEIRMLFVFDP
DRAAIFLVAGDKAGQWSRWYDQAIPLAEARYSEYRAARDKEAGR
VSWDVILLEPVESWFLKLCESDVDTAALIEQAIDRLAVVGPTLGRPLVDTLEHSELRNLKELRPGSRGRSEIRMLFVFDP
DRAAIFLVAGDKAGQWSRWYDQAIPLAEARYSEYRAARDKEAGR
Download Length: 375 bp
>T168994 NZ_CP076268:c3047390-3047055 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG
Antitoxin
Download Length: 110 a.a. Molecular weight: 11928.44 Da Isoelectric Point: 7.0743
>AT168994 WP_231335843.1 NZ_CP059572:4113177-4113506 [Actinomadura graeca]
MSTGRRWQDIKAEAHHRNPELADPQRQAQARAELDAYVAGHHLKELRKAIGKTQAEIAQILGVSQSRVSQIENGDLEAME
LETLRAYATALGGHLDITVSVGPHSIKVA
MSTGRRWQDIKAEAHHRNPELADPQRQAQARAELDAYVAGHHLKELRKAIGKTQAEIAQILGVSQSRVSQIENGDLEAME
LETLRAYATALGGHLDITVSVGPHSIKVA
Download Length: 330 bp
>AT168994 NZ_CP076268:c3047638-3047390 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA