Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1809878..1810581 Replicon chromosome
Accession NZ_CP059569
Organism Kingella oralis strain DSM 18271

Toxin (Protein)


Gene name mqsR Uniprot ID C4GHH4
Locus tag H3L93_RS09680 Protein ID WP_003793643.1
Coordinates 1809878..1810177 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag H3L93_RS09685 Protein ID WP_040558276.1
Coordinates 1810183..1810581 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L93_RS09645 1805332..1806117 - 786 WP_003793654.1 hypothetical protein -
H3L93_RS09650 1806332..1806574 - 243 WP_003793652.1 hypothetical protein -
H3L93_RS09655 1806600..1807184 - 585 WP_003793651.1 hypothetical protein -
H3L93_RS09660 1807370..1807750 - 381 WP_003793649.1 hypothetical protein -
H3L93_RS09665 1807747..1807980 - 234 WP_003793648.1 hypothetical protein -
H3L93_RS09670 1808353..1808814 + 462 WP_003793647.1 hypothetical protein -
H3L93_RS09675 1808819..1809025 - 207 WP_040558068.1 hypothetical protein -
H3L93_RS09680 1809878..1810177 + 300 WP_003793643.1 type II toxin-antitoxin system MqsR family toxin Toxin
H3L93_RS09685 1810183..1810581 + 399 WP_040558276.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
H3L93_RS09690 1810643..1811161 - 519 WP_003793638.1 GNAT family N-acetyltransferase -
H3L93_RS09695 1811151..1811435 - 285 WP_040558274.1 DUF1778 domain-containing protein -
H3L93_RS09700 1811556..1812152 - 597 WP_003793634.1 helix-turn-helix domain-containing protein -
H3L93_RS09705 1812278..1812478 + 201 WP_003793632.1 helix-turn-helix domain-containing protein -
H3L93_RS09710 1812600..1813412 + 813 WP_003793630.1 hypothetical protein -
H3L93_RS09715 1814409..1815164 + 756 WP_003793622.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-98)

Antitoxin

Antitoxin MqsA

(3-131)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11471.15 Da        Isoelectric Point: 5.6382

>T168986 WP_003793643.1 NZ_CP059569:1809878-1810177 [Kingella oralis]
MEKRTPHCSLERVKALLAEEKVRATRVALVGAELLGIDYDEMQNIVSNLNRSDFYKSMTTHADHTIWQDVYRPTVEPYGD
LYIKLTVIDDVLIVSFKER

Download         Length: 300 bp

>T168986 NZ_CP076268:c1339041-1338934 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14650.94 Da        Isoelectric Point: 7.6705

>AT168986 WP_040558276.1 NZ_CP059569:1810183-1810581 [Kingella oralis]
MKCPVCGAAELVHDVRDIPYTYKGKTTIIPQVEADFCPACGESLTAPDESRRMMNLMGEFHKQVNNEIASPSFIRNVRAK
LNLSQREAGELFGGGVNAFSRYETGKAAPPKLLVMMFKMLDSNPSLLEQLRN

Download         Length: 399 bp

>AT168986 NZ_CP076268:1339088-1339154 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C4GHH4

Antitoxin

Source ID Structure

References