Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1648551..1649197 Replicon chromosome
Accession NZ_CP059567
Organism Neisseria shayeganii strain DSM 22244

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H3L94_RS08075 Protein ID WP_182121604.1
Coordinates 1648859..1649197 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H3L94_RS08070 Protein ID WP_182121603.1
Coordinates 1648551..1648862 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3L94_RS08045 1645030..1646100 + 1071 WP_182121598.1 ATP-binding protein -
H3L94_RS08050 1646159..1647103 + 945 WP_182121599.1 hypothetical protein -
H3L94_RS08055 1647220..1647441 + 222 WP_182121600.1 AlpA family phage regulatory protein -
H3L94_RS08060 1647444..1647725 + 282 WP_182121601.1 hypothetical protein -
H3L94_RS08065 1647713..1648234 + 522 WP_182121602.1 phage antirepressor N-terminal domain-containing protein -
H3L94_RS08070 1648551..1648862 - 312 WP_182121603.1 helix-turn-helix domain-containing protein Antitoxin
H3L94_RS08075 1648859..1649197 - 339 WP_182121604.1 toxin Toxin
H3L94_RS08080 1649540..1649857 + 318 WP_182121605.1 hypothetical protein -
H3L94_RS08085 1650057..1650233 + 177 Protein_1562 transposase -
H3L94_RS08090 1650611..1652389 + 1779 WP_182121606.1 biosynthetic-type acetolactate synthase large subunit -
H3L94_RS08095 1652386..1652877 + 492 WP_009118435.1 acetolactate synthase small subunit -
H3L94_RS08100 1652899..1653135 - 237 WP_182121607.1 hypothetical protein -
H3L94_RS08105 1653139..1654078 + 940 WP_182121608.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1650018..1650233 215


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(44-87)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12969.85 Da        Isoelectric Point: 10.0379

>T168981 WP_182121604.1 NZ_CP059567:c1649197-1648859 [Neisseria shayeganii]
VKAVFVELPPFSRYRSDYFTDESYRAFQNELLLNPEKGDVIQGTGGLRKVRVADMQRNKGKRGGSRVIYYWFSARSHFLL
FTVYGKDMQDDLSPDERKALAAMLRTIKETPL

Download         Length: 339 bp

>T168981 NZ_CP076268:c283688-283410 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11566.41 Da        Isoelectric Point: 10.7504

>AT168981 WP_182121603.1 NZ_CP059567:c1648862-1648551 [Neisseria shayeganii]
MKRNLFQELQEGMAAAEQYLQGKATLKTVTVEKSEPVHIEPAEIRAIREQLNLSQAVFAAKLRTSVRTYQGWEQGKTRPN
PQAALLLRMVQKSPKTFKAIASA

Download         Length: 312 bp

>AT168981 NZ_CP076268:c283951-283691 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References