Detailed information of TA system TA168969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 5120586..5121290
• Replicon: chromosome
• Accession: NZ_CP059560
• Organism: Aromatoleum petrolei strain ToN1

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: ToN1_RS23455
• Protein ID: WP_280516657.1
• Coordinates: 5121024..5121290 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: ToN1_RS23450
• Protein ID: WP_169205552.1
• Coordinates: 5120586..5120987 (-)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ToN1_RS23425 (ToN1_48090)	5116205..5116459	-	255	WP_169205548.1	helix-turn-helix transcriptional regulator	-
ToN1_RS23430 (ToN1_48100)	5116567..5117721	+	1155	WP_169205549.1	hypothetical protein	-
ToN1_RS24855 (ToN1_48110)	5117805..5118023	-	219	WP_244861088.1	helix-turn-helix domain-containing protein	-
ToN1_RS23435 (ToN1_48120)	5118065..5118679	-	615	WP_244860870.1	H-NS histone family protein	-
ToN1_RS23440 (ToN1_48130)	5118896..5119456	+	561	WP_169205550.1	phasin family protein	-
ToN1_RS23445 (ToN1_48140)	5119842..5120210	-	369	WP_169205551.1	integration host factor subunit alpha	-
ToN1_RS23450 (ToN1_48150)	5120586..5120987	-	402	WP_169205552.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
ToN1_RS23455 (ToN1_48160)	5121024..5121290	-	267	WP_280516657.1	type II toxin-antitoxin system MqsR family toxin	Toxin
ToN1_RS23460 (ToN1_48180)	5121879..5122379	+	501	WP_169205553.1	hypothetical protein	-
ToN1_RS23465 (ToN1_48190)	5122502..5122948	-	447	WP_169205554.1	hypothetical protein	-
ToN1_RS23470 (ToN1_48210)	5123023..5123412	+	390	WP_169205555.1	hypothetical protein	-
ToN1_RS23475 (ToN1_48220)	5123409..5123696	+	288	WP_169205556.1	hypothetical protein	-
ToN1_RS23480 (ToN1_48230)	5124084..5124701	+	618	WP_169205557.1	response regulator	-
ToN1_RS23485 (ToN1_48240)	5125034..5125537	+	504	WP_169205558.1	hypothetical protein	-
ToN1_RS23490 (ToN1_48250)	5125588..5126052	+	465	WP_169205559.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	5109449..5216441	106992

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (2-78)

Antitoxin

• Antitoxin MqsA (3-131)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 9736.14 Da
• Isoelectric Point: 8.1096

>T168969 WP_280516657.1 NZ_CP059560:c5121290-5121024 [Aromatoleum petrolei]
MEKRTPHCKLAVVKALVEAGMVRTTHAARTGANELGLEFSDMLAVVMALTPADFYKSMTTHADHTLWQDVYRPNTRAGGR
RVPEADSH

Nucleotide

• Length: 267 bp

>T168969 NZ_CP076264:c2755320-2754922 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14566.79 Da
• Isoelectric Point: 7.0834

>AT168969 WP_169205552.1 NZ_CP059560:c5120987-5120586 [Aromatoleum petrolei]
MKCPVCGAAELIHDTRDLPYTYKGETTTIVAVTGDFCPACAESVLDAAESDRVMREMRAFSKQVNAAIVDPSFIANVRKK
LALDQREAAEIFGGGINAFSRYENGKTKPPLALVKLLKVLDRHPDLLNEVRTA

Nucleotide

• Length: 402 bp

>AT168969 NZ_CP076264:c2755547-2755320 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA