Detailed information of TA system TA168966

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 6004752..6005260
• Replicon: chromosome
• Accession: NZ_CP059557
• Organism: Saccharopolyspora gloriosae strain MLY014

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H2Q94_RS26335
• Protein ID: WP_243789843.1
• Coordinates: 6005000..6005260 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H2Q94_RS26330
• Protein ID: WP_243789842.1
• Coordinates: 6004752..6005003 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2Q94_RS26305	6000144..6000335	+	192	WP_243789837.1	hypothetical protein	-
H2Q94_RS26310	6000672..6001172	+	501	WP_243789838.1	CAP domain-containing protein	-
H2Q94_RS26315	6001461..6002300	-	840	WP_243789839.1	carbohydrate ABC transporter permease	-
H2Q94_RS26320	6002300..6003190	-	891	WP_243789840.1	sugar ABC transporter permease	-
H2Q94_RS26325	6003190..6004455	-	1266	WP_243789841.1	ABC transporter substrate-binding protein	-
H2Q94_RS26330	6004752..6005003	+	252	WP_243789842.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H2Q94_RS26335	6005000..6005260	+	261	WP_243789843.1	Txe/YoeB family addiction module toxin	Toxin
H2Q94_RS26340	6005288..6005815	-	528	WP_243789844.1	magnesium transporter	-
H2Q94_RS26345	6005895..6006911	-	1017	WP_243789845.1	type II CAAX endopeptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10441.76 Da
• Isoelectric Point: 8.0689

>T168966 WP_243789843.1 NZ_CP059557:6005000-6005260 [Saccharopolyspora gloriosae]
MKLVWDENAWDDYVWWQTQDRKVLKRINALLKDVERNGNEGIGKPEPLKHGFHGFWSRRITDEHRLVYRLQEDQIQIASC
RYHYGS

Nucleotide

• Length: 261 bp

>T168966 NZ_CP076264:c2051663-2051560 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9372.52 Da
• Isoelectric Point: 4.6882

>AT168966 WP_243789842.1 NZ_CP059557:6004752-6005003 [Saccharopolyspora gloriosae]
MKTMSYSESRAKYAETLNSVVDDREEVVITRSGHEPVVMVALDDYESLKETAYLLKSPENARRLLASIERLEHGGGTTRD
LIE

Nucleotide

• Length: 252 bp

>AT168966 NZ_CP076264:2051522-2051793 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCTTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT