Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Gp49-HTH_37
Location 966618..967237 Replicon chromosome
Accession NZ_CP059488
Organism Acidithiobacillus ferrivorans strain XJFY6S-08

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H2515_RS04975 Protein ID WP_198661046.1
Coordinates 966911..967237 (-) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H2515_RS04970 Protein ID WP_035192166.1
Coordinates 966618..966914 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2515_RS04950 961979..963325 - 1347 WP_198661042.1 sensor domain-containing diguanylate cyclase -
H2515_RS04955 964049..964693 - 645 WP_198661043.1 AAA family ATPase -
H2515_RS04960 964618..965112 - 495 WP_198661044.1 hypothetical protein -
H2515_RS04965 965271..966308 - 1038 WP_198661045.1 hypothetical protein -
H2515_RS04970 966618..966914 - 297 WP_035192166.1 helix-turn-helix domain-containing protein Antitoxin
H2515_RS04975 966911..967237 - 327 WP_198661046.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2515_RS04980 967269..968585 - 1317 WP_198661411.1 integrase family protein -
H2515_RS04985 969238..969504 - 267 WP_198661047.1 hypothetical protein -
H2515_RS04990 969525..969749 - 225 WP_065412568.1 hypothetical protein -
H2515_RS04995 969798..970076 + 279 WP_198661048.1 hypothetical protein -
H2515_RS05000 970087..971052 + 966 WP_198661049.1 DUF932 domain-containing protein -
H2515_RS05005 971079..971366 + 288 WP_198661050.1 YqaJ viral recombinase family protein -
H2515_RS05010 971341..971946 + 606 WP_198661051.1 YqaJ viral recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 964618..989559 24941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(15-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-82)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12370.58 Da        Isoelectric Point: 10.3374

>T168929 WP_198661046.1 NZ_CP059488:c967237-966911 [Acidithiobacillus ferrivorans]
MNWIVSTLDQRVDAELASIPKPILARLVRILEMIEQVGLEHVHEPHIKHLEAKLWEIRAKGPDGIARAIYVTASGKRVVI
LHAFVKKTQKTPKQILEIARQRAREVEE

Download         Length: 327 bp

>T168929 NZ_CP076259:4551224-4551397 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 10614.21 Da        Isoelectric Point: 10.2144

>AT168929 WP_035192166.1 NZ_CP059488:c966914-966618 [Acidithiobacillus ferrivorans]
MTRLTELKKEWMQDADFRAEYVALEEEFAIAHALIQARIKAGLSQAEVARRMGTTQSVVARLEGGGSLPSLRTIQRYASA
TGARAVVKIVPGQSTPVG

Download         Length: 297 bp

>AT168929 NZ_CP076259:4550900-4551196 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References