Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 21300..21885 | Replicon | plasmid p17-84_OXA |
| Accession | NZ_CP059478 | ||
| Organism | Acinetobacter baumannii strain 17-84 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N9CJF7 |
| Locus tag | H2Q98_RS00140 | Protein ID | WP_000897307.1 |
| Coordinates | 21300..21620 (+) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | H2Q98_RS00145 | Protein ID | WP_000369781.1 |
| Coordinates | 21613..21885 (+) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H2Q98_RS00085 | 16646..16888 | - | 243 | WP_001015364.1 | hypothetical protein | - |
| H2Q98_RS00090 | 17037..17261 | + | 225 | WP_002072934.1 | hypothetical protein | - |
| H2Q98_RS00095 | 17365..17568 | + | 204 | WP_182923962.1 | hypothetical protein | - |
| H2Q98_RS00100 | 17573..17848 | + | 276 | WP_005140357.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
| H2Q98_RS00105 | 17832..18122 | + | 291 | WP_000176412.1 | type II toxin-antitoxin system YafQ family toxin | - |
| H2Q98_RS00110 | 18170..18316 | - | 147 | WP_000192351.1 | hypothetical protein | - |
| H2Q98_RS00115 | 18313..18834 | - | 522 | WP_000999915.1 | hypothetical protein | - |
| H2Q98_RS00120 | 19398..19928 | - | 531 | WP_000172759.1 | hypothetical protein | - |
| H2Q98_RS00125 | 20077..20379 | + | 303 | WP_000286964.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H2Q98_RS00130 | 20380..20661 | + | 282 | WP_000985609.1 | putative addiction module antidote protein | - |
| H2Q98_RS00135 | 20741..21160 | - | 420 | WP_001180106.1 | SMI1/KNR4 family protein | - |
| H2Q98_RS00140 | 21300..21620 | + | 321 | WP_000897307.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| H2Q98_RS00145 | 21613..21885 | + | 273 | WP_000369781.1 | helix-turn-helix domain-containing protein | Antitoxin |
| H2Q98_RS00150 | 22378..23853 | + | 1476 | WP_000052512.1 | ABC-F type ribosomal protection protein Msr(E) | - |
| H2Q98_RS00155 | 23909..24793 | + | 885 | WP_000155092.1 | Mph(E) family macrolide 2'-phosphotransferase | - |
| H2Q98_RS00160 | 24937..25806 | + | 870 | Protein_31 | ISNCY family transposase | - |
| H2Q98_RS00165 | 26243..26815 | + | 573 | WP_000193118.1 | translesion error-prone DNA polymerase V autoproteolytic subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaOXA-58 / msr(E) / mph(E) / aph(6)-Id / aph(3'')-Ib / blaPER-1 / aph(3')-VIb / sul2 / aac(3)-IId | - | 1..108715 | 108715 | |
| - | flank | IS/Tn | msr(E) / mph(E) | - | 22378..25806 | 3428 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12187.95 Da Isoelectric Point: 7.1639
>T168900 WP_000897307.1 NZ_CP059478:21300-21620 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG
Download Length: 321 bp
>T168900 NZ_CP076255:c1149822-1149571 [Xanthomonas translucens pv. graminis]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTCGCGGACACCATGGAGCGTGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAT
CTGGCCGAGTGA
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTCGCGGACACCATGGAGCGTGTCGTCAACAACCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTGGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAT
CTGGCCGAGTGA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10149.61 Da Isoelectric Point: 8.6582
>AT168900 WP_000369781.1 NZ_CP059478:21613-21885 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI
Download Length: 273 bp
>AT168900 NZ_CP076255:c1149574-1149317 [Xanthomonas translucens pv. graminis]
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACTACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATCCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTGCGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTGTACAAGGTCGAGGCGGGCATCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG
GTGACGCTTCAGTTCTCGGACAATGCCTGGGAGGACTACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAGCGCAT
CAACGACCTGATCAAAGCCATCCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTGCGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTGTACAAGGTCGAGGCGGGCATCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|