Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 335165..335751 Replicon chromosome
Accession NZ_CP059468
Organism Klebsiella pneumoniae strain BA25665

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag HBJ46_RS01740 Protein ID WP_002920800.1
Coordinates 335165..335533 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag HBJ46_RS01745 Protein ID WP_004174006.1
Coordinates 335530..335751 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HBJ46_RS01720 (330668) 330668..331738 - 1071 WP_043906884.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -
HBJ46_RS01725 (331740) 331740..332585 - 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
HBJ46_RS01730 (332582) 332582..333469 - 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
HBJ46_RS01735 (333576) 333576..334892 - 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
HBJ46_RS01740 (335165) 335165..335533 - 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
HBJ46_RS01745 (335530) 335530..335751 - 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HBJ46_RS01750 (335915) 335915..336628 - 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
HBJ46_RS01755 (336630) 336630..337397 - 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
HBJ46_RS01760 (337394) 337394..338671 - 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
HBJ46_RS01765 (338668) 338668..339594 - 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 329931..338671 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T168873 WP_002920800.1 NZ_CP059468:c335533-335165 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T168873 NZ_CP076250:378162-378296 [Xanthomonas translucens pv. poae]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTTTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT168873 WP_004174006.1 NZ_CP059468:c335751-335530 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT168873 NZ_CP076250:377911-378063 [Xanthomonas translucens pv. poae]
ATGAAGCGACTGTTCACCTTGATGATGCTGACCCTGTTCTGTGCAGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
TGGCAAGGATATGCAGAAGGCCGGCGATAAGGTGGAAAACAAGGCCGACGACTGCAAAGACGGCAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References