Detailed information of TA system TA168861

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): prlF-yhaV (relBE)/YhaV-PrlF
• Location: 895063..895895
• Replicon: chromosome
• Accession: NZ_CP059467
• Organism: Aromatoleum bremense strain PbN1

Toxin (Protein)

• Gene name: yhaV
• Uniprot ID: -
• Locus tag: pbN1_RS04150
• Protein ID: WP_169201285.1
• Coordinates: 895063..895569 (-)
• Length: 169 a.a.

Antitoxin (Protein)

• Gene name: prlF
• Uniprot ID: -
• Locus tag: pbN1_RS04155
• Protein ID: WP_169116722.1
• Coordinates: 895566..895895 (-)
• Length: 110 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
pbN1_RS04120 (pbN1_08450)	890894..891112	-	219	WP_169201281.1	DNA-binding protein	-
pbN1_RS04125 (pbN1_08460)	891241..891513	+	273	WP_169201282.1	type II toxin-antitoxin system ParD family antitoxin	-
pbN1_RS04130 (pbN1_08480)	891982..893115	+	1134	WP_169201283.1	ATP-binding protein	-
pbN1_RS04135 (pbN1_08490)	893230..894195	+	966	WP_169201284.1	DUF4351 domain-containing protein	-
pbN1_RS04140 (pbN1_08500)	894266..894787	+	522	WP_169116724.1	DUF4351 domain-containing protein	-
pbN1_RS20720 (pbN1_08510)	894845..895000	+	156	WP_169116704.1	hypothetical protein	-
pbN1_RS04150 (pbN1_08520)	895063..895569	-	507	WP_169201285.1	type II toxin-antitoxin system YhaV family toxin	Toxin
pbN1_RS04155 (pbN1_08530)	895566..895895	-	330	WP_169116722.1	type II toxin-antitoxin system PrlF family antitoxin	Antitoxin
pbN1_RS04160 (pbN1_08540)	896363..897352	+	990	WP_169116721.1	DUF4351 domain-containing protein	-
pbN1_RS04165 (pbN1_08550)	897377..897628	+	252	WP_169116720.1	DUF4351 domain-containing protein	-
pbN1_RS04170 (pbN1_08560)	897706..898227	+	522	WP_169203981.1	DUF4351 domain-containing protein	-
pbN1_RS20725	898266..898364	-	99	Protein_817	type II toxin-antitoxin system CcdA family antitoxin	-
pbN1_RS04180 (pbN1_08570)	898394..899023	+	630	WP_169203980.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin endonuclease, YhaV (16-152)

Antitoxin

• PrlF antitoxin (8-107)

Sequences

Toxin

Protein

• Length: 169 a.a.
• Molecular weight: 19306.88 Da
• Isoelectric Point: 9.7796

>T168861 WP_169201285.1 NZ_CP059467:c895569-895063 [Aromatoleum bremense]
MSTGKHAPLVIHGWTIFAHPLFLAQIEALAHQVEALKQKDPTGYNKKNASKRLAAITKLAFDVVPQDPARPEYRQGGTLG
DDHKHWFRAKFFQQYRLFFRYHAPSKVIVFAWVNDEDTKRAYESSDDAYRVFRKMLESGHPPDDWNQLLAEARAEGERLQ
RFAAGVTP

Nucleotide

• Length: 507 bp

>T168861 NZ_CP076248:2278301-2278720 [Xanthomonas translucens pv. hordei]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAACCCGAACCCGACCCGGCCGTGCGAGCTTGGTTGAATGA
GCAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTTGCCGAACTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAAAAAGGCCTGGGCGAAGCCCTGGACGGATTGCTCGAACTGTTCAGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCAATTATGCCGAGCTGGCGGTGAAGGCCCGCATAGCCGGGAAGGGTTTTCCAACACCCGACGGATATATTGG
GGCTATTGCGGCCTCCAAGGGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCCGGGCTTACTGTTATCA
ATCCTTGGAACCATCGGTAA

Antitoxin

Protein

• Length: 110 a.a.
• Molecular weight: 11879.34 Da
• Isoelectric Point: 4.6890

>AT168861 WP_169116722.1 NZ_CP059467:c895895-895566 [Aromatoleum bremense]
MPATLDVESTLTDRYQTTVPETVRRALRLGKRDKIHYSIRPSGEVVLTRAASHEGDDPVLGQFLGFLARDIASHPERLQA
VDAGLVQRLQSLVGGIEVDLDAALSADDE

Nucleotide

• Length: 330 bp

>AT168861 NZ_CP076248:2278050-2278304 [Xanthomonas translucens pv. hordei]
ATGGCAATCCTGACAGTGCGGAATGTGCCCGACGAGGTACATCGCGCTCTGCGCTTACGGGCCGCCGAGCATGGCCGCAG
TACAGAGGCGGAGGTCCGCGAGATTCTGGAGAGTGCAGTTAAGTCACAAAAGCGCATCCGCATGGGCGACGCGTTGGCGG
AGCTTGGCCGCCGCGTAGGGCTAACAAACGATGATTTCGCAGTATTGGACCAGGTGCGCGACAAGGTGCCGGCAGAACCG
ATGAGGTTTGAATGA