Detailed information of TA system TA168757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/RelE-HTH
• Location: 2820..3405
• Replicon: plasmid p3.36-1512
• Accession: NZ_CP059389
• Organism: Acinetobacter baumannii strain 36-1512

Toxin (Protein)

• Gene name: higB
• Uniprot ID: N8ZPD7
• Locus tag: H0S62_RS19615
• Protein ID: WP_000897309.1
• Coordinates: 3085..3405 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H0S62_RS19610
• Protein ID: WP_000369780.1
• Coordinates: 2820..3092 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0S62_RS19590	1..951	+	951	WP_001208778.1	replication initiation protein RepM	-
H0S62_RS19595	944..1519	+	576	WP_017725651.1	helix-turn-helix domain-containing protein	-
H0S62_RS19600	1540..1683	+	144	WP_004786602.1	hypothetical protein	-
H0S62_RS19605	1851..2168	-	318	WP_032023430.1	hypothetical protein	-
H0S62_RS19610	2820..3092	-	273	WP_000369780.1	helix-turn-helix domain-containing protein	Antitoxin
H0S62_RS19615	3085..3405	-	321	WP_000897309.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0S62_RS19620	3592..3789	-	198	WP_000476222.1	hypothetical protein	-
H0S62_RS19625	3856..4083	-	228	WP_000921865.1	hypothetical protein	-
H0S62_RS19630	4181..4396	-	216	WP_000071892.1	cold-shock protein	-
H0S62_RS19635	4952..5155	+	204	Protein_9	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..5688	5688

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (41-102)

Antitoxin

• Cro/C1-type helix-turn-helix domain (37-85)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 12209.01 Da
• Isoelectric Point: 7.9835

>T168757 WP_000897309.1 NZ_CP059389:c3405-3085 [Acinetobacter baumannii]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETSILRQLVKEQFHG

Nucleotide

• Length: 321 bp

>T168757 NZ_CP076236:2065-2340 [Escherichia coli O157:H7]
ATGGAACTGAAGTGGAGCAGTAAAGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTAGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10122.63 Da
• Isoelectric Point: 8.6582

>AT168757 WP_000369780.1 NZ_CP059389:c3092-2820 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEIKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI

Nucleotide

• Length: 273 bp

>AT168757 NZ_CP076236:1781-2065 [Escherichia coli O157:H7]
ATGCAAATGAAAAACAATACCGCACAAGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGTTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATTGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Structures

Toxin

• AlphaFold DB: A0A855WJQ3