Detailed information of TA system TA168756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 3353636..3354287
• Replicon: chromosome
• Accession: NZ_CP059386
• Organism: Acinetobacter baumannii strain 36-1512

Toxin (Protein)

• Gene name: higB
• Uniprot ID: S3SZA7
• Locus tag: H0S62_RS16745
• Protein ID: WP_000269903.1
• Coordinates: 3353931..3354287 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H0S62_RS16740
• Protein ID: WP_001140619.1
• Coordinates: 3353636..3353938 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0S62_RS16695	3348668..3348922	+	255	WP_033856686.1	hypothetical protein	-
H0S62_RS16700	3348890..3349435	-	546	Protein_3242	IS5 family transposase	-
H0S62_RS16705	3349363..3349751	-	389	Protein_3243	AAA family ATPase	-
H0S62_RS16710	3349939..3350259	+	321	WP_004704395.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H0S62_RS16715	3350597..3351805	-	1209	WP_000343018.1	IS256-like element ISAba26 family transposase	-
H0S62_RS16720	3351883..3352035	+	153	WP_086238305.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H0S62_RS16725	3352032..3352964	+	933	WP_004739252.1	IS5-like element ISAba13 family transposase	-
H0S62_RS16730	3353097..3353324	+	228	WP_025469214.1	hypothetical protein	-
H0S62_RS16735	3353434..3353643	-	210	WP_000069471.1	hypothetical protein	-
H0S62_RS16740	3353636..3353938	-	303	WP_001140619.1	XRE family transcriptional regulator	Antitoxin
H0S62_RS16745	3353931..3354287	-	357	WP_000269903.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H0S62_RS16750	3354838..3356163	-	1326	Protein_3252	ISNCY family transposase	-
H0S62_RS16755	3356286..3357317	+	1032	WP_181631183.1	two-component sensor histidine kinase AdeS	-
H0S62_RS16760	3357441..3358436	+	996	WP_000373596.1	putative multidrug efflux protein AdeT1	-
H0S62_RS16765	3358510..3359181	-	672	Protein_3255	helix-turn-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3291131..3364719	73588
	-	inside	IScluster/Tn	-	-	3338978..3355839	16861

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-106)

Antitoxin

• HigA2-like, helix-turn-helix domain (13-89)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 13486.45 Da
• Isoelectric Point: 7.1645

>T168756 WP_000269903.1 NZ_CP059386:c3354287-3353931 [Acinetobacter baumannii]
MWTVITTDLFNEWLAQQDQSTQEKVLAALVVLQQQGPSLGRPLVDTVYDSKFTNMKELRVQHRGKPLRAFFAFDPLRQAI
VLCIGDKGGKKRFYKEMLDIADQQYEIHLSTLGDQSNG

Nucleotide

• Length: 357 bp

>T168756 NZ_CP076235:c4953899-4953726 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11206.01 Da
• Isoelectric Point: 6.7282

>AT168756 WP_001140619.1 NZ_CP059386:c3353938-3353636 [Acinetobacter baumannii]
MAKTLQELLANRSPESQARIQQMADELLLETQLHLIREELEISQKELAATLGIKQPSLSAIENRGHDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT168756 NZ_CP076235:c4954223-4953927 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A836MG83