Detailed information of TA system TA168734

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 3971759..3972266
• Replicon: chromosome
• Accession: NZ_CP059348
• Organism: Providencia rettgeri strain ZG2016M39-3

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H0913_RS18365
• Protein ID: WP_181477732.1
• Coordinates: 3972006..3972266 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A4R3NGF7
• Locus tag: H0913_RS18360
• Protein ID: WP_006663215.1
• Coordinates: 3971759..3972013 (+)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0913_RS18335	3966958..3967980	+	1023	WP_181477728.1	UDP-glucose 4-epimerase GalE	-
H0913_RS18340	3968135..3969625	-	1491	WP_181477729.1	glucosyltransferase domain-containing protein	-
H0913_RS18345	3969622..3970542	-	921	WP_181477730.1	glycosyltransferase family 2 protein	-
H0913_RS18350	3970545..3970904	-	360	WP_181477731.1	GtrA family protein	-
H0913_RS18355	3971152..3971655	+	504	WP_006660558.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
H0913_RS18360	3971759..3972013	+	255	WP_006663215.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H0913_RS18365	3972006..3972266	+	261	WP_181477732.1	Txe/YoeB family addiction module toxin	Toxin
H0913_RS18370	3972273..3973094	-	822	WP_036950776.1	serine O-acetyltransferase	-
H0913_RS18375	3973118..3974146	-	1029	WP_108479153.1	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	-
H0913_RS18380	3974156..3974623	-	468	WP_006660561.1	protein-export chaperone SecB	-
H0913_RS18385	3974698..3975135	-	438	WP_181477733.1	rhodanese-like domain-containing protein	-
H0913_RS18390	3975551..3976843	+	1293	WP_036950769.1	murein hydrolase activator EnvC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10294.79 Da
• Isoelectric Point: 9.4082

>T168734 WP_181477732.1 NZ_CP059348:3972006-3972266 [Providencia rettgeri]
MSRLLTWTDQAWDDYLYWQSQDKKTLKRINKLIEDTKRTPFSGIGKPEPLKENLAGFWSRRIDETNRLVYAIENTALVII
ACRYHY

Nucleotide

• Length: 261 bp

>T168734 NZ_CP076235:359364-359639 [Escherichia coli O157:H7]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9596.97 Da
• Isoelectric Point: 5.8373

>AT168734 WP_006663215.1 NZ_CP059348:3971759-3972013 [Providencia rettgeri]
MKTISFSDARSNLKAVLDRVVDDMDTTIITRRDSEAAVVMSLEYYNSLMETIYLLRSPANAEHLNKSIEQFKAGKISERK
LINE

Nucleotide

• Length: 255 bp

>AT168734 NZ_CP076235:359636-359995 [Escherichia coli O157:H7]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A4R3NGF7