168719

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 3975323..3975830 Replicon chromosome
Accession NZ_CP059346
Organism Providencia alcalifaciens strain 1701003

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag H0910_RS18385 Protein ID WP_006663216.1
Coordinates 3975570..3975830 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A4R3NGF7
Locus tag H0910_RS18380 Protein ID WP_006663215.1
Coordinates 3975323..3975577 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0910_RS18360 3970880..3972028 + 1149 WP_181480390.1 polysaccharide biosynthesis/export family protein -
H0910_RS18365 3972034..3972462 + 429 WP_036967040.1 protein-tyrosine-phosphatase -
H0910_RS18370 3972490..3974571 + 2082 WP_181480391.1 polysaccharide biosynthesis tyrosine autokinase -
H0910_RS18375 3974716..3975219 + 504 WP_181480392.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
H0910_RS18380 3975323..3975577 + 255 WP_006663215.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
H0910_RS18385 3975570..3975830 + 261 WP_006663216.1 Txe/YoeB family addiction module toxin Toxin
H0910_RS18390 3975837..3976658 - 822 WP_006660559.1 serine O-acetyltransferase -
H0910_RS18395 3976693..3977721 - 1029 WP_006660560.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
H0910_RS18400 3977731..3978198 - 468 WP_006660561.1 protein-export chaperone SecB -
H0910_RS18405 3978265..3978702 - 438 WP_006660562.1 rhodanese-like domain-containing protein -
H0910_RS18410 3979137..3980429 + 1293 WP_006663217.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3969293..3970501 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10335.84 Da        Isoelectric Point: 9.4082

>T168719 WP_006663216.1 NZ_CP059346:3975570-3975830 [Providencia alcalifaciens]
MSRLLTWTDQAWEDYLYWQNQDKKTLKRINKLIEDTKRTPFSGIGKPEPLKENLAGFWSRRIDETNRLVYAIENTALVII
ACRYHY

Download         Length: 261 bp

>T168719 NZ_CP076232:c2979959-2979852 [Escherichia coli O157:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9596.97 Da        Isoelectric Point: 5.8373

>AT168719 WP_006663215.1 NZ_CP059346:3975323-3975577 [Providencia alcalifaciens]
MKTISFSDARSNLKAVLDRVVDDMDTTIITRRDSEAAVVMSLEYYNSLMETIYLLRSPANAEHLNKSIEQFKAGKISERK
LINE

Download         Length: 255 bp

>AT168719 NZ_CP076232:2980012-2980073 [Escherichia coli O157:H7]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4R3NGF7

References