Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2763928..2764461 Replicon chromosome
Accession NZ_CP059343
Organism Kocuria varians strain 80

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag CIB50_RS12030 Protein ID WP_094394469.1
Coordinates 2763928..2764182 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag CIB50_RS12035 Protein ID WP_094394471.1
Coordinates 2764183..2764461 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CIB50_RS12010 2759564..2760313 + 750 WP_094394463.1 succinate dehydrogenase/fumarate reductase iron-sulfur subunit -
CIB50_RS12015 2760402..2761832 - 1431 WP_094394465.1 anion permease -
CIB50_RS12020 2761997..2762533 - 537 WP_179229881.1 GNAT family N-acetyltransferase -
CIB50_RS12025 2762716..2763881 + 1166 Protein_2345 IS3 family transposase -
CIB50_RS12030 2763928..2764182 - 255 WP_094394469.1 Txe/YoeB family addiction module toxin Toxin
CIB50_RS12035 2764183..2764461 - 279 WP_094394471.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
CIB50_RS12040 2764610..2765878 - 1269 WP_094394473.1 ATP-binding protein -
CIB50_RS12045 2766404..2766724 + 321 WP_094394475.1 hypothetical protein -
CIB50_RS12050 2766726..2767013 + 288 WP_094394478.1 transcriptional regulator -
CIB50_RS12055 2767051..2767437 + 387 WP_094394480.1 hypothetical protein -
CIB50_RS12060 2767884..2769203 + 1320 WP_094394483.1 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2768133..2769203 1070


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-70)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10152.55 Da        Isoelectric Point: 6.7170

>T168710 WP_094394469.1 NZ_CP059343:c2764182-2763928 [Kocuria varians]
MRLVWDEAAWEDYTYWQTADRRILKRINLLIDACLREPFEGIGKPEQLKYGAHGSWSRRINEEHRLVYLVTGEDLVILQS
RYHY

Download         Length: 255 bp

>T168710 NZ_CP076232:1022092-1022265 [Escherichia coli O157:H7]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10399.53 Da        Isoelectric Point: 4.7037

>AT168710 WP_094394471.1 NZ_CP059343:c2764461-2764183 [Kocuria varians]
MSISASEARKTLFPLIERVNEDQEAVEIVSRKGNAVLMPADEYAAWQETAYLFRSPSNARRLLDAYDRARAGKTEVHELD
RSDESVSQARDV

Download         Length: 279 bp

>AT168710 NZ_CP076232:1021768-1022064 [Escherichia coli O157:H7]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References