Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1704593..1705239 Replicon chromosome
Accession NZ_CP059295
Organism Klebsiella pneumoniae strain ER17974.3

Toxin (Protein)


Gene name higB Uniprot ID A0A231WWF9
Locus tag H0490_RS08015 Protein ID WP_004174016.1
Coordinates 1704593..1704940 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A231WWU8
Locus tag H0490_RS08020 Protein ID WP_004174017.1
Coordinates 1704940..1705239 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0490_RS08005 (1700527) 1700527..1701960 + 1434 WP_002920564.1 glycogen synthase GlgA -
H0490_RS08010 (1701978) 1701978..1704425 + 2448 WP_029884517.1 glycogen phosphorylase -
H0490_RS08015 (1704593) 1704593..1704940 + 348 WP_004174016.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H0490_RS08020 (1704940) 1704940..1705239 + 300 WP_004174017.1 XRE family transcriptional regulator Antitoxin
H0490_RS08025 (1705302) 1705302..1706810 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
H0490_RS08030 (1707015) 1707015..1707344 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
H0490_RS08035 (1707395) 1707395..1708225 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
H0490_RS08040 (1708275) 1708275..1709033 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-84)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13518.55 Da        Isoelectric Point: 6.2327

>T168552 WP_004174016.1 NZ_CP059295:1704593-1704940 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFDPLRKAI
VLCAGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

>T168552 NZ_CP076104:4807499-4807930 [Nocardioides sp. LMS-CY]
GTGCTGTTCCTCGACGTCAACGTACTCGTGGGCGCACAGCGCAACGACGACTCTCCGCACGCCCGCGACCTGCGCAACTG
GCTCGAACGAGCCCTGATGGGTCACGAGCCGATCGGCATCAGCGAGCTGGCCCTCAGCGCGATGGTCCGCATCGTCACTC
ATCCGCGCGTCTTCGAGCGTCCCTCTGCCCCCGCCGAGGCAGTCGCGTTCGCCGAGGCCCTGCTCGGTTCCTCGCGAGTG
ACAGCGGTCCGGCCCGCGGCCCGGCACTGGGCGATCTTCACCGAGCTCGTCGCAGGACACCGCCTGCGAGGCAATGAGAT
CCCGGATGCCTACTACGCCGCGATCGCGCTCGAGCAGGGCGCGACGGTCGTGACCGCGGACCGCGGGTTCCAGCGGTACG
GCGTACGCGTGCTCGACCCCACGACCGGGTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10844.64 Da        Isoelectric Point: 10.1464

>AT168552 WP_004174017.1 NZ_CP059295:1704940-1705239 [Klebsiella pneumoniae]
MATLKELMAKQSPESQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQTDNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT168552 NZ_CP076104:4807252-4807497 [Nocardioides sp. LMS-CY]
GTGCGTACCACGGTGAGCATCGACGACGAGCTCCTGGCTGCGGCCAAGGTGCTCGCCGCACGCACGCACCGGACGATCGG
ATCCATCCTGGAGGAGGCCCTGCGCAAGCTGCTCTACGACACAGAGCAGCAGACCGAGACCACGTCGGCGTTGCCCGACT
TCGCCTACTCGGGTGGGCTGCGGCAGGGAGTCGACCTCTACGACAAGGACGCGATGGCCGAGCTGCTCGGCGAGGCGCGT
CGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A231WWF9

Antitoxin

Source ID Structure
AlphaFold DB A0A231WWU8

References