Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 3609422..3610116 | Replicon | chromosome |
Accession | NZ_CP059288 | ||
Organism | Escherichia coli strain 1506 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | S1EXB8 |
Locus tag | H0481_RS17670 | Protein ID | WP_001263493.1 |
Coordinates | 3609422..3609820 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1FJN6 |
Locus tag | H0481_RS17675 | Protein ID | WP_000554757.1 |
Coordinates | 3609823..3610116 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H0481_RS17640 | 3604981..3605439 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
H0481_RS17645 | 3605700..3607157 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
H0481_RS17650 | 3607214..3607735 | - | 522 | Protein_3453 | peptide chain release factor H | - |
H0481_RS17655 | 3607734..3607937 | - | 204 | Protein_3454 | RNA ligase RtcB family protein | - |
H0481_RS17660 | 3608273..3608970 | + | 698 | Protein_3455 | IS1 family transposase | - |
H0481_RS17665 | 3608981..3609412 | - | 432 | WP_181463901.1 | GNAT family N-acetyltransferase | - |
H0481_RS17670 | 3609422..3609820 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
H0481_RS17675 | 3609823..3610116 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
H0481_RS17680 | 3610168..3611220 | - | 1053 | WP_000691315.1 | DNA polymerase IV | - |
H0481_RS17685 | 3611282..3612826 | + | 1545 | WP_181463902.1 | recombinase family protein | - |
H0481_RS17695 | 3614379..3615087 | + | 709 | Protein_3462 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | yagV/ecpE | 3544133..3621068 | 76935 | |
- | inside | IScluster/Tn | - | - | 3608467..3616620 | 8153 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T168540 WP_001263493.1 NZ_CP059288:c3609820-3609422 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T168540 NZ_CP076050:1481896-1482180 [Cupriavidus metallidurans]
ATGATCCGCTCGCTCTCCGACAAGACGACGGCCGCCATCTATTGCGGCCAGTCCGTTCACACACTGCCCGCTCACATTCA
GGCCGATGCGCTGCGCAAGCTCGCGATCCTCGACGCTGCGTCGTCTCTTCCCGATATGGTCGCGCCGCCCGCAAACCGGC
TGGAACCCGTTCTCGGCAAGCGCCGCGGACACTGGCGCGTGCGCATTCAAGGTCCGTGGCATCTCTGCTTTCGCTTCATC
AACGGCGAAGCGTGGGACGTCGGCATCGCCGAATACGAGGAATGA
ATGATCCGCTCGCTCTCCGACAAGACGACGGCCGCCATCTATTGCGGCCAGTCCGTTCACACACTGCCCGCTCACATTCA
GGCCGATGCGCTGCGCAAGCTCGCGATCCTCGACGCTGCGTCGTCTCTTCCCGATATGGTCGCGCCGCCCGCAAACCGGC
TGGAACCCGTTCTCGGCAAGCGCCGCGGACACTGGCGCGTGCGCATTCAAGGTCCGTGGCATCTCTGCTTTCGCTTCATC
AACGGCGAAGCGTGGGACGTCGGCATCGCCGAATACGAGGAATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT168540 WP_000554757.1 NZ_CP059288:c3610116-3609823 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT168540 NZ_CP076050:1482190-1482537 [Cupriavidus metallidurans]
ATGACAATCAAGCGCGAAGACTTGCGGCGCGCGGATTTTCGCAGCATTGCCACCGGCCGGCCGATCCCGCCTGCACACCC
CGGCGAGGTCCTGGAAACCGAGTTCATGGCGCCAAACGAACTGTCGGCAGAAGCACTGGCGGTGGCCTTGCATATGGCGC
CGCAACGAATTCACGATATCGTGCGACGTCAGCGAGCTATATCGCCAGACACCGCCCTGAGGCTGGCCCGCTATTTCGGC
ACTAGTGCGGAATTCTGGGCGGGCCTCCAGGCCGCGTATGCACTGCGGCTGGCGCGCGCGGCTGCAGGGCCGATCATCGA
GCGCGACATCCAGCCGCTGACGGCATGA
ATGACAATCAAGCGCGAAGACTTGCGGCGCGCGGATTTTCGCAGCATTGCCACCGGCCGGCCGATCCCGCCTGCACACCC
CGGCGAGGTCCTGGAAACCGAGTTCATGGCGCCAAACGAACTGTCGGCAGAAGCACTGGCGGTGGCCTTGCATATGGCGC
CGCAACGAATTCACGATATCGTGCGACGTCAGCGAGCTATATCGCCAGACACCGCCCTGAGGCTGGCCCGCTATTTCGGC
ACTAGTGCGGAATTCTGGGCGGGCCTCCAGGCCGCGTATGCACTGCGGCTGGCGCGCGCGGCTGCAGGGCCGATCATCGA
GCGCGACATCCAGCCGCTGACGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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