Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 587879..588678 Replicon chromosome
Accession NZ_CP059283
Organism Escherichia coli strain SY3626_hybrid

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag H0155_RS02855 Protein ID WP_000347273.1
Coordinates 587879..588343 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag H0155_RS02860 Protein ID WP_001307405.1
Coordinates 588343..588678 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0155_RS02825 582880..583314 - 435 WP_000948842.1 PTS sugar transporter subunit IIA -
H0155_RS02830 583332..584210 - 879 WP_001295548.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
H0155_RS02835 584200..584979 - 780 WP_000406209.1 PTS mannose/fructose/sorbose/N-acetylgalactosamine transporter subunit IIC -
H0155_RS02840 584990..585463 - 474 WP_001336162.1 PTS N-acetylgalactosamine transporter subunit IIB -
H0155_RS02845 585486..586766 - 1281 WP_176580464.1 tagatose-bisphosphate aldolase subunit KbaZ -
H0155_RS02850 587015..587824 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
H0155_RS02855 587879..588343 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
H0155_RS02860 588343..588678 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
H0155_RS02865 588827..590398 - 1572 WP_001273753.1 galactarate dehydratase -
H0155_RS02870 590773..592107 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
H0155_RS02875 592123..592893 + 771 WP_001058209.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T168494 WP_000347273.1 NZ_CP059283:c588343-587879 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

>T168494 NZ_CP076028:c884127-883939 [Staphylococcus sp. MZ8]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT168494 WP_001307405.1 NZ_CP059283:c588678-588343 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp

>AT168494 NZ_CP076028:c884416-884156 [Staphylococcus sp. MZ8]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References