Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 59927..60196 Replicon plasmid pC9
Accession NZ_CP059282
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name hok Uniprot ID P11895
Locus tag H0272_RS24395 Protein ID WP_001312861.1
Coordinates 60038..60196 (+) Length 53 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 59927..59992 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS24375 55148..57106 + 1959 WP_042045562.1 ParB/RepB/Spo0J family partition protein -
H0272_RS24380 57161..57595 + 435 WP_000845949.1 conjugation system SOS inhibitor PsiB -
H0272_RS24385 57592..58311 + 720 WP_033550421.1 plasmid SOS inhibition protein A -
- 58323..58425 + 103 NuclAT_1 - -
- 58323..58425 + 103 NuclAT_1 - -
- 58323..58425 + 103 NuclAT_1 - -
- 58323..58425 + 103 NuclAT_1 - -
H0272_RS24390 58471..59840 + 1370 WP_085947770.1 IS3-like element IS150 family transposase -
- 59867..59994 + 128 NuclAT_0 - -
- 59867..59994 + 128 NuclAT_0 - -
- 59867..59994 + 128 NuclAT_0 - -
- 59867..59994 + 128 NuclAT_0 - -
- 59927..59992 - 66 - - Antitoxin
H0272_RS24395 60038..60196 + 159 WP_001312861.1 type I toxin-antitoxin system Hok family toxin Toxin
H0272_RS24400 60639..60974 + 336 WP_013023876.1 hypothetical protein -
H0272_RS24405 60887..61093 + 207 WP_000275859.1 hypothetical protein -
H0272_RS24410 61118..61405 + 288 WP_000107535.1 hypothetical protein -
H0272_RS24415 61524..62345 + 822 WP_001234469.1 DUF945 domain-containing protein -
H0272_RS24420 62642..63244 - 603 WP_000243712.1 transglycosylase SLT domain-containing protein -
H0272_RS24425 63574..63957 + 384 WP_001151566.1 relaxosome protein TraM -
H0272_RS24430 64091..64768 + 678 WP_001348626.1 PAS domain-containing protein -
H0272_RS24435 64856..65083 + 228 WP_001254388.1 conjugal transfer relaxosome protein TraY -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / mph(A) / sul1 / qacE / aadA5 / dfrA17 senB 1..140350 140350


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-48)


Sequences


Toxin        


Download         Length: 53 a.a.        Molecular weight: 6082.32 Da        Isoelectric Point: 9.2584

>T168492 WP_001312861.1 NZ_CP059282:60038-60196 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 159 bp

>T168492 NZ_CP076027:c2476534-2476268 [Staphylococcus sp. MZ7]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 66 bp

>AT168492 NZ_CP059282:c59992-59927 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB P11895


Antitoxin

Download structure file

References