Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 59927..60196 | Replicon | plasmid pC9 |
Accession | NZ_CP059282 | ||
Organism | Escherichia coli strain C9 |
Toxin (Protein)
Gene name | hok | Uniprot ID | P11895 |
Locus tag | H0272_RS24395 | Protein ID | WP_001312861.1 |
Coordinates | 60038..60196 (+) | Length | 53 a.a. |
Antitoxin (RNA)
Gene name | sok | ||
Locus tag | - | ||
Coordinates | 59927..59992 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H0272_RS24375 | 55148..57106 | + | 1959 | WP_042045562.1 | ParB/RepB/Spo0J family partition protein | - |
H0272_RS24380 | 57161..57595 | + | 435 | WP_000845949.1 | conjugation system SOS inhibitor PsiB | - |
H0272_RS24385 | 57592..58311 | + | 720 | WP_033550421.1 | plasmid SOS inhibition protein A | - |
- | 58323..58425 | + | 103 | NuclAT_1 | - | - |
- | 58323..58425 | + | 103 | NuclAT_1 | - | - |
- | 58323..58425 | + | 103 | NuclAT_1 | - | - |
- | 58323..58425 | + | 103 | NuclAT_1 | - | - |
H0272_RS24390 | 58471..59840 | + | 1370 | WP_085947770.1 | IS3-like element IS150 family transposase | - |
- | 59867..59994 | + | 128 | NuclAT_0 | - | - |
- | 59867..59994 | + | 128 | NuclAT_0 | - | - |
- | 59867..59994 | + | 128 | NuclAT_0 | - | - |
- | 59867..59994 | + | 128 | NuclAT_0 | - | - |
- | 59927..59992 | - | 66 | - | - | Antitoxin |
H0272_RS24395 | 60038..60196 | + | 159 | WP_001312861.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
H0272_RS24400 | 60639..60974 | + | 336 | WP_013023876.1 | hypothetical protein | - |
H0272_RS24405 | 60887..61093 | + | 207 | WP_000275859.1 | hypothetical protein | - |
H0272_RS24410 | 61118..61405 | + | 288 | WP_000107535.1 | hypothetical protein | - |
H0272_RS24415 | 61524..62345 | + | 822 | WP_001234469.1 | DUF945 domain-containing protein | - |
H0272_RS24420 | 62642..63244 | - | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
H0272_RS24425 | 63574..63957 | + | 384 | WP_001151566.1 | relaxosome protein TraM | - |
H0272_RS24430 | 64091..64768 | + | 678 | WP_001348626.1 | PAS domain-containing protein | - |
H0272_RS24435 | 64856..65083 | + | 228 | WP_001254388.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | erm(B) / mph(A) / sul1 / qacE / aadA5 / dfrA17 | senB | 1..140350 | 140350 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 53 a.a. Molecular weight: 6082.32 Da Isoelectric Point: 9.2584
>T168492 WP_001312861.1 NZ_CP059282:60038-60196 [Escherichia coli]
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
MKLPRSSLVWCVLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 159 bp
>T168492 NZ_CP076027:c2476534-2476268 [Staphylococcus sp. MZ7]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 66 bp
>AT168492 NZ_CP059282:c59992-59927 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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