Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3677575..3678077 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag H0272_RS17965 Protein ID WP_000767822.1
Coordinates 3677575..3677829 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H0272_RS17970 Protein ID WP_001259255.1
Coordinates 3677826..3678077 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS17945 3674068..3675426 - 1359 WP_000019194.1 putrescine/proton symporter PlaP -
H0272_RS17950 3675416..3675478 - 63 WP_010723108.1 membrane protein YoeI -
H0272_RS17955 3675693..3676622 - 930 WP_000803366.1 LysR family transcriptional regulator -
H0272_RS17960 3676668..3677492 - 825 WP_000754737.1 SDR family oxidoreductase -
H0272_RS17965 3677575..3677829 - 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H0272_RS17970 3677826..3678077 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H0272_RS17975 3678360..3678410 + 51 WP_001364200.1 his operon leader peptide -
H0272_RS17980 3678556..3679455 + 900 WP_000131782.1 ATP phosphoribosyltransferase -
H0272_RS17985 3679461..3680765 + 1305 WP_001546022.1 histidinol dehydrogenase -
H0272_RS17990 3680762..3681832 + 1071 WP_000108941.1 histidinol-phosphate transaminase -
H0272_RS17995 3681832..3682899 + 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T168487 WP_000767822.1 NZ_CP059281:c3677829-3677575 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T168487 NZ_CP076027:873939-874190 [Staphylococcus sp. MZ7]
ATGAATAACCGCGAACAAATTGAACAATCAATTATCAGTGCTAGTGCCTATAACGGTAATGACACAGAGGGATTACTAAA
AGAGGTTGAAGACGTGTATAAGAAAGCGCAAGCGTTTGATGAAATACTTGATGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTGTTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAACAGGAA
AATGAGTATTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT168487 WP_001259255.1 NZ_CP059281:c3678077-3677826 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT168487 NZ_CP076027:874180-874353 [Staphylococcus sp. MZ7]
ATGAGTATTAGTGTAGGAGATAAAGTGTATAACCATGAAACAAACGAAAGTCTAGAGATTGTGCAATTGGTCGGAGATAT
TAGAGATACACATTATAAACTGTCCGATGATTCAGTTATTAGCATTATAGATTTTATTACTAAACCAATTTATCTAATTA
AGGGGGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References