168462

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 480501..481819 Replicon chromosome
Accession NZ_CP059281
Organism Escherichia coli strain C9

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag H0272_RS02370 Protein ID WP_001262467.1
Coordinates 480501..481508 (-) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag H0272_RS02375 Protein ID WP_001312177.1
Coordinates 481508..481819 (-) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H0272_RS02340 475711..475902 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
H0272_RS02345 475899..477578 + 1680 Protein_457 cellulose biosynthesis protein BcsG -
H0272_RS02350 477664..477771 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
H0272_RS02355 478147..478254 - 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
- 478311..478368 + 58 NuclAT_26 - -
- 478311..478368 + 58 NuclAT_26 - -
- 478311..478368 + 58 NuclAT_26 - -
- 478311..478368 + 58 NuclAT_26 - -
H0272_RS02360 478630..478737 - 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- 478786..478851 + 66 NuclAT_27 - -
- 478786..478851 + 66 NuclAT_27 - -
- 478786..478851 + 66 NuclAT_27 - -
- 478786..478851 + 66 NuclAT_27 - -
H0272_RS02365 479213..480484 + 1272 WP_001545666.1 amino acid permease -
H0272_RS02370 480501..481508 - 1008 WP_001262467.1 HipA domain-containing protein Toxin
H0272_RS02375 481508..481819 - 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
H0272_RS02380 481804..482127 - 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
H0272_RS02385 482352..483365 - 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
H0272_RS02390 483362..484345 - 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
H0272_RS02395 484356..485258 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
H0272_RS02400 485268..486287 - 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T168462 WP_001262467.1 NZ_CP059281:c481508-480501 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

>T168462 NZ_CP076008:c4735565-4735032 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT168462 WP_001312177.1 NZ_CP059281:c481819-481508 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp

>AT168462 NZ_CP076008:c4735842-4735576 [Klebsiella pneumoniae subsp. pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References