Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | HipBST/HipA(toxin) |
| Location | 4933665..4934983 | Replicon | chromosome |
| Accession | NZ_CP059279 | ||
| Organism | Escherichia coli strain C7 | ||
Toxin (Protein)
| Gene name | HipT | Uniprot ID | F4T5A3 |
| Locus tag | H0271_RS23795 | Protein ID | WP_001262467.1 |
| Coordinates | 4933665..4934672 (-) | Length | 336 a.a. |
Antitoxin (Protein)
| Gene name | HipS | Uniprot ID | F4T5A4 |
| Locus tag | H0271_RS23800 | Protein ID | WP_001312177.1 |
| Coordinates | 4934672..4934983 (-) | Length | 104 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H0271_RS23765 | 4928875..4929066 | + | 192 | WP_000988308.1 | cellulose biosynthesis protein BcsF | - |
| H0271_RS23770 | 4929063..4930742 | + | 1680 | Protein_4642 | cellulose biosynthesis protein BcsG | - |
| H0271_RS23775 | 4930828..4930935 | - | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| H0271_RS23780 | 4931311..4931418 | - | 108 | WP_000170748.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 4931475..4931532 | + | 58 | NuclAT_26 | - | - |
| - | 4931475..4931532 | + | 58 | NuclAT_26 | - | - |
| - | 4931475..4931532 | + | 58 | NuclAT_26 | - | - |
| - | 4931475..4931532 | + | 58 | NuclAT_26 | - | - |
| H0271_RS23785 | 4931794..4931901 | - | 108 | WP_001295224.1 | type I toxin-antitoxin system toxin Ldr family protein | - |
| - | 4931950..4932015 | + | 66 | NuclAT_27 | - | - |
| - | 4931950..4932015 | + | 66 | NuclAT_27 | - | - |
| - | 4931950..4932015 | + | 66 | NuclAT_27 | - | - |
| - | 4931950..4932015 | + | 66 | NuclAT_27 | - | - |
| H0271_RS23790 | 4932377..4933648 | + | 1272 | WP_001545666.1 | amino acid permease | - |
| H0271_RS23795 | 4933665..4934672 | - | 1008 | WP_001262467.1 | HipA domain-containing protein | Toxin |
| H0271_RS23800 | 4934672..4934983 | - | 312 | WP_001312177.1 | HipA N-terminal domain-containing protein | Antitoxin |
| H0271_RS23805 | 4934968..4935291 | - | 324 | WP_000563102.1 | helix-turn-helix transcriptional regulator | - |
| H0271_RS23810 | 4935516..4936529 | - | 1014 | WP_000103572.1 | dipeptide ABC transporter ATP-binding subunit DppF | - |
| H0271_RS23815 | 4936526..4937509 | - | 984 | WP_001196477.1 | dipeptide ABC transporter ATP-binding protein | - |
| H0271_RS23820 | 4937520..4938422 | - | 903 | WP_000084677.1 | dipeptide ABC transporter permease DppC | - |
| H0271_RS23825 | 4938432..4939451 | - | 1020 | WP_000938855.1 | dipeptide ABC transporter permease DppB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 336 a.a. Molecular weight: 38320.60 Da Isoelectric Point: 5.5965
>T168455 WP_001262467.1 NZ_CP059279:c4934672-4933665 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL
Download Length: 1008 bp
>T168455 NZ_CP076008:364035-364382 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
ATGTGGGATGTGGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCTTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGGCAATAAGGATGGCATAAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA
Antitoxin
Download Length: 104 a.a. Molecular weight: 11821.47 Da Isoelectric Point: 6.0609
>AT168455 WP_001312177.1 NZ_CP059279:c4934983-4934672 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE
Download Length: 312 bp
>AT168455 NZ_CP076008:364382-364681 [Klebsiella pneumoniae subsp. pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGAAAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGACTGATAACGACCCTCGGCTTTCGACCCTAAAAAGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3K2ZTB5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3L3HKE2 |