Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2410133..2410656 Replicon chromosome
Accession NZ_CP059180
Organism Staphylococcus aureus strain SH1000

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag SAURSH1000_RS11880 Protein ID WP_000074048.1
Coordinates 2410133..2410399 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag SAURSH1000_RS11885 Protein ID WP_000587616.1
Coordinates 2410399..2410656 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SAURSH1000_RS11860 (SAURSH1000_002370) 2405440..2406627 - 1188 WP_000026194.1 MFS transporter -
SAURSH1000_RS11865 (SAURSH1000_002371) 2407023..2407799 - 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
SAURSH1000_RS11870 (SAURSH1000_002372) 2407792..2408454 - 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
SAURSH1000_RS11875 (SAURSH1000_002373) 2408702..2409778 - 1077 WP_001076671.1 M42 family metallopeptidase -
SAURSH1000_RS11880 (SAURSH1000_002374) 2410133..2410399 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
SAURSH1000_RS11885 (SAURSH1000_002375) 2410399..2410656 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SAURSH1000_RS11890 (SAURSH1000_002376) 2411015..2411470 + 456 WP_000732082.1 DUF1307 domain-containing protein -
SAURSH1000_RS11895 (SAURSH1000_002377) 2411638..2413215 - 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
SAURSH1000_RS11900 (SAURSH1000_002378) 2413410..2414159 + 750 WP_000072443.1 CPBP family lipoprotein N-acylation protein LnsB -
SAURSH1000_RS11905 (SAURSH1000_002379) 2414383..2415576 - 1194 WP_000675401.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T168423 WP_000074048.1 NZ_CP059180:c2410399-2410133 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T168423 NZ_CP075881:5707818-5708036 [Klebsiella michiganensis]
ATGTCTGATAAAACATTAACCAAAATAGACTATTTGATGCGTTTACGACGCTGTCAGACAATTGATACGCTGGAGCGCGT
AATTGAAAAAAATAAATATGAACTTTCCGATAATGAACTGGCGGTATTTTACTCTGCGGCCGATCATCGTCTTGCAGAGC
TGACGATGAATAAACTGTATGACAAGATCCCCCCTTCAGTCTGGAAATTTATCCGCTAG

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT168423 WP_000587616.1 NZ_CP059180:c2410656-2410399 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT168423 NZ_CP075881:5707417-5707791 [Klebsiella michiganensis]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCGCAGCTTAAATTTCTCTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTGGAAGAGAGCAACCACGGCTGGGTTAATGATCCAACCTCGGCTGTCAATCTTCAACTTAATGAATTGATCGAGC
ACATTGCCGCGTTTGCACTTAATTATAAAATTAAGTACGCAGAGGATAATAAGCTGATTACCCAGATTGACGAATATCTG
GATGACACTTTCGTCTTGTTCAGCAACTACGGCATTAACAGCGCAGATCTGCAGAAATGGCGTAAATCTGGCAATCGGTT
ATTCCGCTGCTTTGTCAACGCCAGTCGGGAAAACCCGGCCAGTCTTTCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
PDB 7V6W
PDB 7V5Z
PDB 7V5Y
AlphaFold DB W8TQT5

References