Detailed information of TA system TA168421

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2378632..2378816
• Replicon: chromosome
• Accession: NZ_CP059180
• Organism: Staphylococcus aureus strain SH1000

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: Q2FVI9
• Locus tag: SAURSH1000_RS11740
• Protein ID: WP_000482650.1
• Coordinates: 2378709..2378816 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2378632..2378692 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAURSH1000_RS11725 (SAURSH1000_002343)	2374162..2374329	-	168	WP_001790576.1	hypothetical protein	-
SAURSH1000_RS11730 (SAURSH1000_002344)	2374560..2376293	-	1734	WP_000486494.1	ABC transporter ATP-binding protein	-
SAURSH1000_RS11735 (SAURSH1000_002345)	2376318..2378081	-	1764	WP_001064838.1	ABC transporter ATP-binding protein	-
-	2378632..2378692	+	61	-	-	Antitoxin
SAURSH1000_RS11740 (SAURSH1000_002346)	2378709..2378816	-	108	WP_000482650.1	type I toxin-antitoxin system Fst family toxin	Toxin
SAURSH1000_RS11745 (SAURSH1000_002347)	2378950..2379336	-	387	WP_000779358.1	flippase GtxA	-
SAURSH1000_RS11750 (SAURSH1000_002348)	2379604..2380746	+	1143	WP_001176863.1	glycerate kinase	-
SAURSH1000_RS11755 (SAURSH1000_002349)	2380806..2381465	+	660	WP_000831298.1	membrane protein	-
SAURSH1000_RS11760 (SAURSH1000_002350)	2381647..2382858	+	1212	WP_001192075.1	multidrug effflux MFS transporter	-
SAURSH1000_RS11765 (SAURSH1000_002351)	2382981..2383454	-	474	WP_000456489.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4011.78 Da
• Isoelectric Point: 11.0582

>T168421 WP_000482650.1 NZ_CP059180:c2378816-2378709 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T168421 NZ_CP075881:3054945-3055277 [Klebsiella michiganensis]
ATGGACAGAGGGGAAATCTGGCTCGTTTCACTGGATCCGATTGCAGGCCACGAGCAAAGCGGAAAACGTCCGGTGCTTAT
CGTATCGAAGGCATCGTTTAACAAGCTGACCCGGTTACCCGTTGTTGTTCCCATCACCAGCGGTGGAAATTTTGCTCGCA
CGGCTGGTTTCACCGTTTCACTGGAAGGGGCAGGGATAAAAACGTTGGGCGTTATTCGCTGCGACCAGCCCAGAACCATT
GATATAGCTGCCCGGAACGGCAAGCGGCTGGAACGCATACCAGACGCGGTGGTAAATGAAGTGCTTGCCAGGCTGGATGC
AATTTTACGTTAA

Antitoxin

Nucleotide

• Length: 61 bp

>AT168421 NZ_CP059180:2378632-2378692 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2C9TTS8

Antitoxin