Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2353280..2353797 | Replicon | chromosome |
| Accession | NZ_CP059180 | ||
| Organism | Staphylococcus aureus strain SH1000 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | T1YC79 |
| Locus tag | SAURSH1000_RS11605 | Protein ID | WP_000113262.1 |
| Coordinates | 2353280..2353546 (-) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | T1YB60 |
| Locus tag | SAURSH1000_RS11610 | Protein ID | WP_000584499.1 |
| Coordinates | 2353546..2353797 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| SAURSH1000_RS11575 (SAURSH1000_002313) | 2348706..2349242 | - | 537 | WP_000169315.1 | GNAT family N-acetyltransferase | - |
| SAURSH1000_RS11580 (SAURSH1000_002314) | 2349475..2350299 | - | 825 | WP_000572040.1 | formate/nitrite transporter family protein | - |
| SAURSH1000_RS11585 (SAURSH1000_002315) | 2350516..2350698 | - | 183 | WP_000230294.1 | hypothetical protein | - |
| SAURSH1000_RS11590 (SAURSH1000_002316) | 2350782..2351249 | - | 468 | WP_000153344.1 | SRPBCC domain-containing protein | - |
| SAURSH1000_RS11595 (SAURSH1000_002317) | 2351435..2352985 | - | 1551 | WP_000727762.1 | zinc ABC transporter substrate-binding lipoprotein AdcA | - |
| SAURSH1000_RS11600 (SAURSH1000_002318) | 2353174..2353245 | - | 72 | Protein_2240 | hypothetical protein | - |
| SAURSH1000_RS11605 (SAURSH1000_002319) | 2353280..2353546 | - | 267 | WP_000113262.1 | Txe/YoeB family addiction module toxin | Toxin |
| SAURSH1000_RS11610 (SAURSH1000_002320) | 2353546..2353797 | - | 252 | WP_000584499.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| SAURSH1000_RS11615 (SAURSH1000_002321) | 2353962..2354063 | - | 102 | WP_001791744.1 | hypothetical protein | - |
| SAURSH1000_RS11620 (SAURSH1000_002322) | 2354070..2354669 | - | 600 | WP_000162813.1 | DsbA family protein | - |
| SAURSH1000_RS11625 (SAURSH1000_002323) | 2354688..2355050 | - | 363 | WP_000819843.1 | DUF4467 domain-containing protein | - |
| SAURSH1000_RS11630 (SAURSH1000_002324) | 2355305..2356555 | + | 1251 | WP_001012222.1 | FemA/FemB family glycyltransferase FmhA | - |
| SAURSH1000_RS11635 (SAURSH1000_002325) | 2356652..2357383 | - | 732 | WP_000615461.1 | amino acid ABC transporter ATP-binding protein | - |
| SAURSH1000_RS11640 (SAURSH1000_002326) | 2357380..2358099 | - | 720 | WP_000479576.1 | amino acid ABC transporter permease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10437.95 Da Isoelectric Point: 9.9143
>T168420 WP_000113262.1 NZ_CP059180:c2353546-2353280 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY
Download Length: 267 bp
>T168420 NZ_CP075881:1945369-1945779 [Klebsiella michiganensis]
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG
GTGGTCCTGTGGCAATCTGATTTACGCATCTCGTGGCGAGCGCAGTGGTTTTCGCTGCTGATGCACGGCGTGGTGGCGGC
GCTGGTGCTGCTGATGCCCTGGCCGCTGAGCTATACCCCGCTGTGGCTGATACTGCTGTCGCTGGTGGTGTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCAGGGAGAAATCAAGCTGCTGATCGACTCCCGTCTGCGCTGGCAAAAGGCG
GAGTGGGATATCATCGGCACCCCGTGGGTGATTAACAGCGGAATGCTGCTGCGCCTGCGGAATACGGAAAACCAACGAAC
CCAGCATTTGTGGGTCGCGGCGGATAGCATGGACGCGGGAGAATGGCGAGACCTGCGTCGGCTGGTGTTGCTAAAACCGA
CGCAAGAGTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9433.60 Da Isoelectric Point: 4.3407
>AT168420 WP_000584499.1 NZ_CP059180:c2353797-2353546 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV
Download Length: 252 bp
>AT168420 NZ_CP075881:1945122-1945388 [Klebsiella michiganensis]
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGACATTAACAATAAAGCCCGCATCCACTGGGCATGCCGTCGAGGTATGCGTGAACTCGATATCTCCATCATGCCGTT
TTTCGAGCATGAGTACGACACGCTCAGCGATGGCGACAAAGCGTTATTCATCCGCCTGCTGGAAAACGACGATCCGGATC
TGTTCAACTGGTTGATGAATCATGGCGAGCCGGCTGATGCAGAACTGCAGCGGATGGTAAAATTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|