Detailed information of TA system TA168413

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 18109..18635
• Replicon: plasmid pLp900-2
• Accession: NZ_CP059170
• Organism: Lactiplantibacillus plantarum strain Lp900

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: Lp900_RS15335
• Protein ID: WP_097037724.1
• Coordinates: 18109..18375 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: Lp900_RS15340
• Protein ID: WP_204768826.1
• Coordinates: 18372..18635 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
Lp900_RS15310	13214..13729	-	516	WP_097037794.1	ECF transporter S component	-
Lp900_RS15315	13733..14122	-	390	WP_097037795.1	DUF4430 domain-containing protein	-
Lp900_RS15320	14171..14710	-	540	WP_097037796.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
Lp900_RS15325	14745..16991	-	2247	WP_097037797.1	ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	-
Lp900_RS15330	17511..17933	+	423	WP_097037723.1	YjdF family protein	-
Lp900_RS15335	18109..18375	-	267	WP_097037724.1	Txe/YoeB family addiction module toxin	Toxin
Lp900_RS15340	18372..18635	-	264	WP_204768826.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
Lp900_RS15345	18739..19134	-	396	WP_204768827.1	hypothetical protein	-
Lp900_RS15350	19140..19784	+	645	Protein_21	IS256-like element IS1310 family transposase	-
Lp900_RS15360	20668..20826	+	159	Protein_23	transposase	-
Lp900_RS15365	20850..21197	+	348	WP_204768829.1	replication protein	-
Lp900_RS15370	21457..21738	+	282	WP_204768830.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	-
Lp900_RS15375	21728..22153	+	426	Protein_26	hypothetical protein	-
Lp900_RS15380	22231..22503	-	273	WP_204768831.1	hypothetical protein	-
Lp900_RS15385	22526..22753	-	228	WP_204768832.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..48831	48831
	-	flank	IS/Tn	-	-	19140..19835	695

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (29-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10409.99 Da
• Isoelectric Point: 10.3873

>T168413 WP_097037724.1 NZ_CP059170:c18375-18109 [Lactiplantibacillus plantarum]
MSSYQVEIKNSAKSDLKKLKKSNLKAQFLKTVAILKENPYQPTQSFEKLQPTSRGLYSRRLNAQHRVVYRVDEELKKVYI
YAAWSHYE

Nucleotide

• Length: 267 bp

>T168413 NZ_CP075854:101686-101967 [Escherichia coli]
ATGACTTATGAACTGGAATTTGAGCGCAGGGCCCTGAAAGAATGGCATAAGCTCGGTCATACAGTCCGTGAGCAGTTCAA
AAAGAAACTGTCAGAACGCCTGAAAAATCCAAGGGTCCCTGCTGCCAGGCTACATGGTCATACTGACCGTTATAAAATCA
AGCTTCGTGCATCTGGTTACAGGCTCGTCTATCAGGTGATTGATGAGAAAATTGTTTTGCTCGTTATTGCTGTAGGAAAA
AGGGAAAGCAGTGAGGTCTACCAGATGGCTGATATTCGCTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9973.97 Da
• Isoelectric Point: 4.0995

>AT168413 WP_204768826.1 NZ_CP059170:c18635-18372 [Lactiplantibacillus plantarum]
MENYTPTKARQNLYQILKDINQQKKPVTITPANGDEDQAAIIISKKDWDSIAETLYLENTGTLAKVREREDDESGFTNVD
DLDWDNL

Nucleotide

• Length: 264 bp

>AT168413 NZ_CP075854:101445-101696 [Escherichia coli]
ATGAGTTACCAGATTTTGACCACGACAGCAGCAAGTATTACTGAGCTGAAAAAAAATCCTATGGGCACGGTAGCCGAAGG
TGAAGGAGGGGCCGTTGCAATCCTGAACCGAAATGAGCCTGCGTTCTACTGTGTCCCTCCGGAACTTTATGCCTACTACC
GGGAGCTCGCCGAAGATGCTGAGCTAAACGCAATTGCTGATGAAAGAATGAAGAATCCGGACATTGTGAAGGTTAGTCTG
GATGACTTATGA