Detailed information of TA system TA168405

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): SprA2-SprA2AS/-
• Location: 2547528..2547712
• Replicon: chromosome
• Accession: NZ_CP059156
• Organism: Staphylococcus aureus strain WKZ-1

Toxin (Protein)

• Gene name: SprA2
• Uniprot ID: A0A2P7CQJ7
• Locus tag: HTZ90_RS12710
• Protein ID: WP_000482647.1
• Coordinates: 2547605..2547712 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	SprA2AS
Locus tag	-
Coordinates	2547528..2547588 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ90_RS12695	2543038..2543205	-	168	Protein_2460	hypothetical protein	-
HTZ90_RS12700	2543436..2545169	-	1734	WP_000486505.1	ABC transporter ATP-binding protein/permease	-
HTZ90_RS12705	2545194..2546957	-	1764	WP_001064829.1	ABC transporter ATP-binding protein/permease	-
-	2547528..2547588	+	61	-	-	Antitoxin
HTZ90_RS12710	2547605..2547712	-	108	WP_000482647.1	type I toxin-antitoxin system Fst family toxin	Toxin
HTZ90_RS12715	2547846..2548232	-	387	WP_000779351.1	flippase GtxA	-
HTZ90_RS12720	2548500..2549642	+	1143	WP_001176855.1	glycerate kinase	-
HTZ90_RS12725	2549702..2550361	+	660	WP_000831298.1	membrane protein	-
HTZ90_RS12730	2550543..2551754	+	1212	WP_001191919.1	multidrug effflux MFS transporter	-
HTZ90_RS12735	2551877..2552350	-	474	WP_000456496.1	GyrI-like domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 4012.76 Da
• Isoelectric Point: 10.4935

>T168405 WP_000482647.1 NZ_CP059156:c2547712-2547605 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Nucleotide

• Length: 108 bp

>T168405 NZ_CP075852:3912437-3912772 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Nucleotide

• Length: 61 bp

>AT168405 NZ_CP059156:2547528-2547588 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Structures

Toxin

• AlphaFold DB: A0A2P7CQJ7

Antitoxin