Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2522226..2522743 Replicon chromosome
Accession NZ_CP059156
Organism Staphylococcus aureus strain WKZ-1

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag HTZ90_RS12575 Protein ID WP_000251928.1
Coordinates 2522226..2522492 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag HTZ90_RS12580 Protein ID WP_000584497.1
Coordinates 2522492..2522743 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ90_RS12550 2517434..2517970 - 537 WP_180821748.1 GNAT family N-acetyltransferase -
HTZ90_RS12555 2518438..2519262 - 825 WP_000594640.1 formate/nitrite transporter family protein -
HTZ90_RS12560 2519465..2519647 - 183 WP_000079140.1 hypothetical protein -
HTZ90_RS12565 2519733..2520200 - 468 WP_000153340.1 SRPBCC domain-containing protein -
HTZ90_RS12570 2520386..2521933 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HTZ90_RS12575 2522226..2522492 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
HTZ90_RS12580 2522492..2522743 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HTZ90_RS12585 2522907..2523007 - 101 Protein_2438 hypothetical protein -
HTZ90_RS12590 2523014..2523613 - 600 WP_000162804.1 DsbA family protein -
HTZ90_RS12595 2523632..2523994 - 363 WP_000819843.1 DUF4467 domain-containing protein -
HTZ90_RS12600 2524249..2525499 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
HTZ90_RS12605 2525596..2526327 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
HTZ90_RS12610 2526324..2527043 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T168404 WP_000251928.1 NZ_CP059156:c2522492-2522226 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T168404 NZ_CP075852:3776097-3776504 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT168404 WP_000584497.1 NZ_CP059156:c2522743-2522492 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT168404 NZ_CP075852:3775850-3776116 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References