Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/- |
| Location | 2091723..2092146 | Replicon | chromosome |
| Accession | NZ_CP059156 | ||
| Organism | Staphylococcus aureus strain WKZ-1 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A5S9I4Y6 |
| Locus tag | HTZ90_RS10270 | Protein ID | WP_001065091.1 |
| Coordinates | 2091895..2092146 (-) | Length | 84 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | A0A0E0VQM8 |
| Locus tag | HTZ90_RS10265 | Protein ID | WP_000028422.1 |
| Coordinates | 2091723..2091905 (-) | Length | 61 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HTZ90_RS10220 | 2087109..2088770 | - | 1662 | WP_000625088.1 | terminase large subunit | - |
| HTZ90_RS10225 | 2088767..2089111 | - | 345 | WP_000402904.1 | hypothetical protein | - |
| HTZ90_RS10230 | 2089241..2089540 | - | 300 | WP_000988336.1 | HNH endonuclease | - |
| HTZ90_RS10235 | 2089772..2090188 | - | 417 | WP_000590122.1 | hypothetical protein | - |
| HTZ90_RS10240 | 2090216..2090416 | - | 201 | WP_000265043.1 | DUF1514 family protein | - |
| HTZ90_RS10245 | 2090416..2090565 | - | 150 | WP_000595265.1 | transcriptional activator RinB | - |
| HTZ90_RS10250 | 2090562..2090948 | - | 387 | WP_000592207.1 | hypothetical protein | - |
| HTZ90_RS10255 | 2090945..2091151 | - | 207 | WP_000195803.1 | DUF1381 domain-containing protein | - |
| HTZ90_RS10260 | 2091188..2091730 | - | 543 | WP_000185659.1 | dUTP pyrophosphatase | - |
| HTZ90_RS10265 | 2091723..2091905 | - | 183 | WP_000028422.1 | hypothetical protein | Antitoxin |
| HTZ90_RS10270 | 2091895..2092146 | - | 252 | WP_001065091.1 | DUF1024 family protein | Toxin |
| HTZ90_RS10275 | 2092139..2092306 | - | 168 | WP_001624242.1 | hypothetical protein | - |
| HTZ90_RS10280 | 2092318..2092560 | - | 243 | WP_000131366.1 | hypothetical protein | - |
| HTZ90_RS10285 | 2092564..2092932 | - | 369 | WP_000101274.1 | hypothetical protein | - |
| HTZ90_RS10290 | 2092945..2093254 | - | 310 | Protein_1993 | RusA family crossover junction endodeoxyribonuclease | - |
| HTZ90_RS10295 | 2093263..2093481 | - | 219 | WP_000338531.1 | hypothetical protein | - |
| HTZ90_RS10300 | 2093488..2094361 | - | 874 | Protein_1995 | DnaD domain protein | - |
| HTZ90_RS10305 | 2094391..2094861 | - | 471 | WP_000934764.1 | single-stranded DNA-binding protein | - |
| HTZ90_RS10310 | 2094862..2095479 | - | 618 | WP_071621397.1 | MBL fold metallo-hydrolase | - |
| HTZ90_RS10315 | 2095560..2096480 | - | 921 | WP_000138472.1 | recombinase RecT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | scn / chp / sak / sea / hlb / tsst-1 / groEL | 2064055..2134988 | 70933 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 84 a.a. Molecular weight: 9349.22 Da Isoelectric Point: 3.9473
>T168399 WP_001065091.1 NZ_CP059156:c2092146-2091895 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH
Download Length: 252 bp
>T168399 NZ_CP075852:c2485019-2484708 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA
Antitoxin
Download Length: 61 a.a. Molecular weight: 6741.63 Da Isoelectric Point: 4.2658
>AT168399 WP_000028422.1 NZ_CP059156:c2091905-2091723 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND
Download Length: 183 bp
>AT168399 NZ_CP075852:c2484707-2484417 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5S9I4Y6 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VQM8 |