Detailed information of TA system TA168397

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2068412..2068711
• Replicon: chromosome
• Accession: NZ_CP059156
• Organism: Staphylococcus aureus strain WKZ-1

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: HTZ90_RS10120
• Protein ID: WP_011447039.1
• Coordinates: 2068535..2068711 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2068412..2068467 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ90_RS10080	2063742..2064002	+	261	WP_001791826.1	hypothetical protein	-
HTZ90_RS10085	2064055..2064405	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
HTZ90_RS10090	2065091..2065540	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
HTZ90_RS10095	2065635..2065970	-	336	Protein_1954	SH3 domain-containing protein	-
HTZ90_RS10100	2066620..2067111	-	492	WP_000919350.1	staphylokinase	-
HTZ90_RS10105	2067302..2068057	-	756	WP_000861038.1	CHAP domain-containing protein	-
HTZ90_RS10110	2068069..2068323	-	255	WP_000611512.1	phage holin	-
HTZ90_RS10115	2068375..2068482	+	108	WP_001791821.1	hypothetical protein	-
-	2068404..2068543	+	140	NuclAT_0	-	-
-	2068404..2068543	+	140	NuclAT_0	-	-
-	2068404..2068543	+	140	NuclAT_0	-	-
-	2068404..2068543	+	140	NuclAT_0	-	-
-	2068412..2068467	+	56	-	-	Antitoxin
HTZ90_RS10120	2068535..2068711	-	177	WP_011447039.1	putative holin-like toxin	Toxin
HTZ90_RS10125	2068820..2069593	-	774	WP_000750406.1	staphylococcal enterotoxin type A	-
HTZ90_RS10130	2070014..2070388	-	375	WP_000340977.1	hypothetical protein	-
HTZ90_RS10135	2070444..2070731	-	288	WP_001040259.1	hypothetical protein	-
HTZ90_RS10140	2070778..2070930	-	153	WP_001153681.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / sea / hlb / tsst-1 / groEL	2064055..2134988	70933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T168397 WP_011447039.1 NZ_CP059156:c2068711-2068535 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T168397 NZ_CP075852:c2103658-2103308 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT168397 NZ_CP059156:2068412-2068467 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin