Detailed information of TA system TA168390

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 1576614..1577193
• Replicon: chromosome
• Accession: NZ_CP059156
• Organism: Staphylococcus aureus strain WKZ-1

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: HTZ90_RS07495
• Protein ID: WP_001025401.1
• Coordinates: 1576948..1577193 (-)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	1576614..1576979 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HTZ90_RS07455	1573357..1573914	-	558	WP_000645048.1	DUF2815 family protein	-
HTZ90_RS07460	1573940..1575106	-	1167	WP_180821674.1	DUF2800 domain-containing protein	-
HTZ90_RS07465	1575103..1575465	-	363	WP_000985972.1	hypothetical protein	-
HTZ90_RS07470	1575480..1575803	-	324	WP_000174998.1	hypothetical protein	-
HTZ90_RS07475	1575882..1576043	-	162	WP_001285954.1	DUF1270 domain-containing protein	-
HTZ90_RS07480	1576056..1576319	-	264	WP_001124157.1	helix-turn-helix domain-containing protein	-
HTZ90_RS07485	1576344..1576559	-	216	WP_001097552.1	hypothetical protein	-
HTZ90_RS07490	1576614..1576979	+	366	WP_001128433.1	hypothetical protein	Antitoxin
HTZ90_RS07495	1576948..1577193	-	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
HTZ90_RS07500	1577243..1577461	-	219	WP_001001383.1	hypothetical protein	-
HTZ90_RS07505	1577477..1578032	-	556	Protein_1475	phage antirepressor KilAC domain-containing protein	-
HTZ90_RS07510	1578058..1578285	-	228	WP_001030311.1	hypothetical protein	-
HTZ90_RS07515	1578457..1579071	+	615	WP_000801423.1	XRE family transcriptional regulator	-
HTZ90_RS07520	1579087..1580007	+	921	WP_000348133.1	3'-5' exoribonuclease	-
HTZ90_RS07525	1580103..1580285	+	183	WP_000705240.1	hypothetical protein	-
HTZ90_RS07530	1580322..1580468	+	147	WP_180821745.1	hypothetical protein	-
HTZ90_RS07535	1580468..1581079	-	612	Protein_1481	ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1536097..1600060	63963

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T168390 WP_001025401.1 NZ_CP059156:c1577193-1576948 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

>T168390 NZ_CP075852:490366-490473 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 366 bp

>AT168390 NZ_CP059156:1576614-1576979 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin