168389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 1569583..1570006 Replicon chromosome
Accession NZ_CP059156
Organism Staphylococcus aureus strain WKZ-1

Toxin (Protein)


Gene name higB Uniprot ID A0A6B5KJM6
Locus tag HTZ90_RS07420 Protein ID WP_001065110.1
Coordinates 1569755..1570006 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E1X568
Locus tag HTZ90_RS07415 Protein ID WP_000028425.1
Coordinates 1569583..1569765 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ90_RS07375 1564976..1565266 - 291 WP_000665205.1 VRR-NUC domain-containing protein -
HTZ90_RS07380 1565400..1565504 + 105 WP_180821673.1 hypothetical protein -
HTZ90_RS07385 1565607..1568054 - 2448 WP_000884879.1 virulence-associated E family protein -
HTZ90_RS07390 1568107..1568307 - 201 WP_000265258.1 DUF1514 family protein -
HTZ90_RS07395 1568375..1568527 - 153 WP_000595237.1 transcriptional activator RinB -
HTZ90_RS07400 1568520..1568756 - 237 WP_000483477.1 hypothetical protein -
HTZ90_RS07405 1568781..1569017 - 237 WP_000195806.1 DUF1381 domain-containing protein -
HTZ90_RS07410 1569054..1569590 - 537 WP_000185703.1 dUTPase -
HTZ90_RS07415 1569583..1569765 - 183 WP_000028425.1 hypothetical protein Antitoxin
HTZ90_RS07420 1569755..1570006 - 252 WP_001065110.1 DUF1024 family protein Toxin
HTZ90_RS07425 1570021..1570263 - 243 WP_000132193.1 hypothetical protein -
HTZ90_RS07430 1570278..1570478 - 201 WP_000235324.1 hypothetical protein -
HTZ90_RS07435 1570481..1570738 - 258 WP_000022730.1 DUF3310 domain-containing protein -
HTZ90_RS07440 1570738..1571139 - 402 WP_000113974.1 PVL family protein -
HTZ90_RS07445 1571139..1571324 - 186 WP_001164629.1 DUF3113 family protein -
HTZ90_RS07450 1571337..1573289 - 1953 WP_001802096.1 DNA polymerase -
HTZ90_RS07455 1573357..1573914 - 558 WP_000645048.1 DUF2815 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1536097..1600060 63963


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9405.32 Da        Isoelectric Point: 3.8051

>T168389 WP_001065110.1 NZ_CP059156:c1570006-1569755 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKARAFDEILEGLPNAMQDALKEDIGLDEAVGIMTGQVVYKYEEEQE
NEY

Download         Length: 252 bp

>T168389 NZ_CP075852:489830-489937 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6781.65 Da        Isoelectric Point: 4.4421

>AT168389 WP_000028425.1 NZ_CP059156:c1569765-1569583 [Staphylococcus aureus]
MSISVGDKVYNHETNESLEIVQLVGDIRDTHYKLSDGSIISLIDFVIKPIHLIKEAQEND

Download         Length: 183 bp

>AT168389 NZ_CP075852:c489783-489717 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6B5KJM6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1X568

References