Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2571777..2571961 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name SprA2 Uniprot ID A0A2P7CQJ7
Locus tag HTZ91_RS12835 Protein ID WP_000482647.1
Coordinates 2571854..2571961 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2571777..2571837 (+)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS12820 2567287..2567454 - 168 Protein_2485 hypothetical protein -
HTZ91_RS12825 2567685..2569418 - 1734 WP_000486505.1 ABC transporter ATP-binding protein/permease -
HTZ91_RS12830 2569443..2571206 - 1764 WP_001064829.1 ABC transporter ATP-binding protein/permease -
- 2571777..2571837 + 61 - - Antitoxin
HTZ91_RS12835 2571854..2571961 - 108 WP_000482647.1 type I toxin-antitoxin system Fst family toxin Toxin
HTZ91_RS12840 2572095..2572481 - 387 WP_000779351.1 flippase GtxA -
HTZ91_RS12845 2572749..2573891 + 1143 WP_001176855.1 glycerate kinase -
HTZ91_RS12850 2573951..2574610 + 660 WP_000831298.1 membrane protein -
HTZ91_RS12855 2574792..2576003 + 1212 WP_001191919.1 multidrug effflux MFS transporter -
HTZ91_RS12860 2576126..2576599 - 474 WP_000456496.1 GyrI-like domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 36 a.a.        Molecular weight: 4012.76 Da        Isoelectric Point: 10.4935

>T168385 WP_000482647.1 NZ_CP059155:c2571961-2571854 [Staphylococcus aureus]
MFNLLIDIMTSALSGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T168385 NZ_CP075740:48913-49065 [Escherichia coli]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCATCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 61 bp

>AT168385 NZ_CP059155:2571777-2571837 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A2P7CQJ7


Antitoxin

Download structure file

References