Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2546475..2546992 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag HTZ91_RS12700 Protein ID WP_000251928.1
Coordinates 2546475..2546741 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag HTZ91_RS12705 Protein ID WP_000584497.1
Coordinates 2546741..2546992 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS12675 2541683..2542219 - 537 WP_180821748.1 GNAT family N-acetyltransferase -
HTZ91_RS12680 2542687..2543511 - 825 WP_000594640.1 formate/nitrite transporter family protein -
HTZ91_RS12685 2543714..2543896 - 183 WP_000079140.1 hypothetical protein -
HTZ91_RS12690 2543982..2544449 - 468 WP_000153340.1 SRPBCC domain-containing protein -
HTZ91_RS12695 2544635..2546182 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
HTZ91_RS12700 2546475..2546741 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
HTZ91_RS12705 2546741..2546992 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HTZ91_RS12710 2547156..2547256 - 101 Protein_2463 hypothetical protein -
HTZ91_RS12715 2547263..2547862 - 600 WP_000162804.1 DsbA family protein -
HTZ91_RS12720 2547881..2548243 - 363 WP_000819843.1 DUF4467 domain-containing protein -
HTZ91_RS12725 2548498..2549748 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
HTZ91_RS12730 2549845..2550576 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
HTZ91_RS12735 2550573..2551292 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T168384 WP_000251928.1 NZ_CP059155:c2546741-2546475 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T168384 NZ_CP075740:2265-2540 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAGTCCCTGACACAGGCTCCGGTCATTCTGTTAACTCATCCACGTATGGGGGAACAGTTATTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTACTGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT168384 WP_000584497.1 NZ_CP059155:c2546992-2546741 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT168384 NZ_CP075740:1981-2265 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGCTCCCGGGGCTGGATTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References