Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/-
Location 2115972..2116395 Replicon chromosome
Accession NZ_CP059155
Organism Staphylococcus aureus strain WKZ-2

Toxin (Protein)


Gene name higB Uniprot ID A0A5S9I4Y6
Locus tag HTZ91_RS10390 Protein ID WP_001065091.1
Coordinates 2116144..2116395 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0E0VQM8
Locus tag HTZ91_RS10385 Protein ID WP_000028422.1
Coordinates 2115972..2116154 (-) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HTZ91_RS10340 2111358..2113019 - 1662 WP_000625088.1 terminase large subunit -
HTZ91_RS10345 2113016..2113360 - 345 WP_000402904.1 hypothetical protein -
HTZ91_RS10350 2113490..2113789 - 300 WP_000988336.1 HNH endonuclease -
HTZ91_RS10355 2114021..2114437 - 417 WP_000590122.1 hypothetical protein -
HTZ91_RS10360 2114465..2114665 - 201 WP_000265043.1 DUF1514 family protein -
HTZ91_RS10365 2114665..2114814 - 150 WP_000595265.1 transcriptional activator RinB -
HTZ91_RS10370 2114811..2115197 - 387 WP_000592207.1 hypothetical protein -
HTZ91_RS10375 2115194..2115400 - 207 WP_000195803.1 DUF1381 domain-containing protein -
HTZ91_RS10380 2115437..2115979 - 543 WP_000185659.1 dUTP pyrophosphatase -
HTZ91_RS10385 2115972..2116154 - 183 WP_000028422.1 hypothetical protein Antitoxin
HTZ91_RS10390 2116144..2116395 - 252 WP_001065091.1 DUF1024 family protein Toxin
HTZ91_RS10395 2116388..2116555 - 168 WP_001624242.1 hypothetical protein -
HTZ91_RS10400 2116567..2116809 - 243 WP_000131366.1 hypothetical protein -
HTZ91_RS10405 2116813..2117181 - 369 WP_000101274.1 hypothetical protein -
HTZ91_RS10410 2117194..2117503 - 310 Protein_2017 RusA family crossover junction endodeoxyribonuclease -
HTZ91_RS10415 2117512..2117730 - 219 WP_000338531.1 hypothetical protein -
HTZ91_RS10420 2117737..2118610 - 874 Protein_2019 DnaD domain protein -
HTZ91_RS10425 2118640..2119110 - 471 WP_000934764.1 single-stranded DNA-binding protein -
HTZ91_RS10430 2119111..2119728 - 618 WP_071621397.1 MBL fold metallo-hydrolase -
HTZ91_RS10435 2119809..2120729 - 921 WP_000138472.1 recombinase RecT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - map / hlb / scn / chp / sak / sea / hlb / tsst-1 / groEL 2036286..2156257 119971


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF1024

(1-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9349.22 Da        Isoelectric Point: 3.9473

>T168379 WP_001065091.1 NZ_CP059155:c2116395-2116144 [Staphylococcus aureus]
MNNREQIEQSVISASAYNGNDTEGLLKEIEDVYKKAQAFDEILEGMTNAIQHSVKEGVELDEAVGIMAGQVVYKYEEEQE
NEH

Download         Length: 252 bp

>T168379 NZ_CP075737:c4007446-4007168 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6741.63 Da        Isoelectric Point: 4.2658

>AT168379 WP_000028422.1 NZ_CP059155:c2116154-2115972 [Staphylococcus aureus]
MSISVGDKVFNPETNSTLEIVQLVGDIRDTHYKLSDGSIISLIDFVVKPIHLIKEEQEND

Download         Length: 183 bp

>AT168379 NZ_CP075737:c4007709-4007449 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5S9I4Y6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VQM8

References